Study On Synthesis Of 5-Methoxy-6-nitro-[1, 2, 5] Oxadiazolo [3, 4-b] Pyridine-1-oxide

Furoxans are widely used in pharmaceutical and energetic materials fields.Pyridofuro-xans are very important one in this kind of compound. This dissertation designed a new compound:5-methoxy-6-nitro-[1,2,5]oxadiazolo[3,4-b]pyridine-l-oxide, it could be a novel nucleobase intermediate,which has important research value and broad prospect in medical field.According to the referrence and mechanism analysis, a best synthesis route was determined.5-methoxy-6-nitro-[1,2,5]oxadiazolo[3,4-b]pyridine-l-oxide was synthesized from 2,6-dichloropyridine by methoxylation, two-step nitration, azidotion and heat liberation of nitrogen.Single factor experiments were carried to determine the most effective conditions such as material ratio, reaction time and temperature. Each intermediate was characterized by the melting point determination, infrared spectroscopy(IR), mass spectra(MS),~1H nuclear magnetic resonance(~1HNMR), the results showed that they are in line with the target products. It proved that synthesis route was feasible.