One-pot Conversion Of Carboxylic Acids Into Nitriles Under Microwave Irradiation And Reduction Of Chiral Amino Acids And Cleavage Of Ether Bonds Using Boron Trifluoride

We study on the method of conversion of carboxylic acids into nitriles by one-pot reaction under microwave irradiation, reduction of chiral amino acids and cleavage of ether bond using boron trifluoride. Satisfactory yields were obtained. This thesis consists of four chapters.Chapter 1: prefaceChapter 2: Carboxylic acids were converted into nitriles by one-pot reactions with hydroxylamine hydrochloride and zinc powerd catalyzed by PEG400 under microwave irradiation. The results showed that the method has features of lower cost, speediness, less pollution, high yield and ease of work-up.Chapter 3: Chiral amino acids were reduced into chiral amino alcohols by the boron trifluoride-sodium borohydride system. The results showed that the method has inexpensive, safe, high yield and ease of work-up.Chapter 4: Ether bond were cleaved at room temperature by the system of boron trifluoride-sodium iodide. The results showed that the method has mild, inexpensive and highly selective for the cleavage of aliphatic ethers.