Study On The Preparation And The Quality Standards In Naotai Tablets

Objective:Naotai freckle-Preparation of research and quality standards for the treatment of cardiovascular and cerebrovascular diseases of the new film-coating formulations and provide agents on the basis of quality control.Methods:prescription analysis and retrieval line screening to determine the extraction process routes to ligustrazine, ferulic acid,flavonoids leaching capacity of the indicators of the impact of leaching factors were selected through single factor compared to the total flavonoids retention rate as an index Optimization Alcohol Shen process conditions;By comparing the experimental study of alcohol extract separate drying and mixing different temperatures and dry conditions under vacuum drying on the ligustrazine and ferulic acid by HPLC impact of the collapse of indicators, the combination of granulation process and compression parameters gifted freckle-election Naotai best molding process conditions;done by TLC Identification; using High Performance Liquid Chromatography (HPLC) determination, and methods of inspection.Results:Rhizome ligustici wallichii ethanol extraction, Astragalus, A, B water mention. Ethanolic extract optimum conditions:40% ethanol, heating to extract two times, and alcohol respectively 10,8 times, the extraction time is 2.0,1.5 hours. Water extract optimum conditions:extracting three times,and the water was 10 times the medicine,8 times,8 times the extraction time of 2.0 hours,1.5 hours,1.5 hours.Mention condensed water from liquid to a relative density of 1.20,by adding 95% ethanol,the volume of liquid containing alcohol was 60%, standing 24 hours after filtration,and alcohol extracts mixed vacuum drying at 70℃.Process conditions:drug powders:Lactose:microcrystalline cellulose 14:3:3,3% PVP= (K30) 95% ethanol solution for adhesives,0.5% of the silica powder to help flow of 1% Magnesium stearate is lubricated. Astragalus,Rhizome ligustici wallichii TLC no negative interference, A,B TLC no double negative interference, ligustrazine,ferulic acid Determination feasible,good repeatability.Conclusion:Preparation of viable, reliable quality standards and can be used for industrial production.