| Polybrominated biphenyl ethers(PBDEs) are a group of additive flame retardants. They are widely used in commercial and household products due to its high efficiency flame retardants, good thermostability, small additive amount, the small influence on the material properties. Since not chemically bound to materials PBDEs can be easily released. As the decline of other typical persistent organic pollutants (such as PCBs) in the environment, PBDEs'environmental concentrations are rising. They have been recognized as ubiquitous enironmental pollutants.As the largest industial city in China, many kinds of manufacturing are intensive and the useage of polybrominated diphenyl ethers is large in Shanghai.Shanghai is the largest city in china, the production and usage of polybrominated diphenyl ethers as flame retardants in products such as electrical and electronic products are intensive,It's worthy to pay close attention to the potential health risks of environment. Until now, people think the way of food that PBDEs exposure to human body is the main way.the research of indoor and outdoor air is less,but air is the primary media and important storage that human body exposure to PBDEs. Indoor air is particularly health significance because of long exposure and easy accumulation. At present, the research about PBDEs in Shanghai atmosphere is less, only DR.HanWenLiang's research. Meanwhile, polybrominated biphenyl ethers have been viewed with potential interference with endocrine. It embodies in many aspects of interference, such as direct damage to thyroid; changes thyroid hormone levels, accelerates the thyroid hormone clear;competes combining TTR with thyroid hormone,etc.Therefore,this research selects home,office,computer room and supermarket to study, and study the PBDEs'interference effect with thyroid has practical significance.We studied PBDEs collected from four different indoor environment of Shanghai with passive sampling technique,included its concentrations, composition, seasonal changes,the possible source and human exposure.The main results are as follows:1)In winter, the home indoor air's average concentration of∑7PBDEs were 7.879pg/m3,the average concentration of BDE-209 were 86.545 pg/m3. The library's indoor air average concentration of∑7PBDEs were 10.898 pg/m3 in Donghua university,the average concentration of BDE-209 were 99.715 pg/m3.The computer room's indoor air average concentration of∑7PBDEs were 15.433 pg/m3, the average concentration of BDE-209 were 109.092 pg/m3.The Tesco supermarket's indoor air average concentration of∑7PBDEs were 10.982 pg/m3,the average concentration of BDE-209 were 96.185 pg/m3.2)In summer, the home indoor air's average concentration of∑7PBDEs were 14.087pg/m3,the average concentration of BDE-209 were 236.688 pg/m3. The library's indoor air average concentration of∑7PBDEs were 36.547pg/m3 in Donghua university,the average concentration of BDE-209 were 113.805pg/m3.The computer room's indoor air average concentration of∑7PBDEs were 18.220pg/m3, the average concentration of BDE-209 were 227.031pg/m3.The Tesco supermarket's indoor air average concentration of∑7PBDEs were 18.915pg/m3,the average concentration of BDE-209 were 92.335pg/m3.3)In all four different types of indoor environment,the concentration of computer room is the highest,while the lowest is home. Congener profiles showed that BDE-209 was the major component, indicating that DeBDE was the major commercial PBDEs used in Shanghai.Compared with foreign reports,the home indoor air concentration of∑7PBDEs were lower than the other countries, but the concentration of BDE-209 were obviously higher than others.4)we analysed the TTR activity of environmental samples,showing that the combination of TTR and T4 is decling with the increase of the content of PBDEs.The interfence with thyroid hormone is higner.
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