| This experiment is conducted to evaluate the effects of CdAA to absorb cadmium in corn-soybean diets of growing pigs.One hundred and ninety two Duroc * Landrace * Yorkshine growing pigs, (average initial weight of 27.6 +1.44 kg), were randomly allotted to four groups. Each group consisted of three pens of sixteen pigs (females and castrated males balanced). In the period of their growth, the pigs received three types of same basal diet (control) (3.11, 3.08, 3.03 Meal/kg, DE, respectively; 16.51, 15.90, 13.81% CP, respectively), supplemented with 0.5% CdAA (T1), 0.5 % CdAA and 10mg/kg cadmium (T2),10mg/kg mg/kg (T3), respectively. Feed and water were provided ad libitum. The experiment diets were fed daily for 83d after being pretested for 7d. Feed consumption was recorded every week and no pigs were found died during experiment. At the end of feeding trial, Four pigs from each pen were selected based on similar live weight (sex balanced) and slaughtered. While the pigs were sacrificed, pathological changes of T4 were recorded and the samples of blood (serum), muscle, liver, kidney were collected for laboratory analysis.The cadmium concentration on muscle, liver, and kidney cortex from pigs were determined. The average wet weight cadmium concentration in muscle, liver, and kidney of Tl were 0.03, 0.24, 0.57 mg/kg, respectively, which were depressed by90.9 % (P<0.01), 81.4 % (P<0.01), 75.2 % (P<0.01), respectively and accord with the international tiptop standard (European Union standard). Compared with T3, the corresP<0nding concentrations in T2 decreased by 78.7 % (P<0.01), 77.7% (P<0.01), 76.8% (P<0.01), respectively. Cadmium concentration in blood of Tl decreased by 82.6 % (P<0.01) compared with control. The corresP<0nding concentration of T2 decreased by 71.4 % (P<0.01) compared with T3.The result of feeding trial showed that there was no significance in ADG and F/G between Tl and control. ADG in T2 increased by 15.0 % (P<0.01) and F/G ration of this treat decreased by 13.2% (P<0.01) compared with T3.Pathological changes were mainly found in T3 including a little tumefactive change of liver, kidney, spleen, thymus, and intestine lymphaden. Ulcer was found hi stomachic mucosa of this treatment.Determination of hemoglobin level from each treatment indicated that CdAA can increase hemoglobin concentration. Compared with control, Hb in Tl increased by 10.6% (P<0.01). Hb in T2 increased by 24.2% (P<0.01) compared to T3.The analysis of GSH-Px and SOD activities in serum showed that there was an upward tendency in treatments supplemented with CdAA. Tl was the highest among four's.CdAA supplement can improve immune function in growing swine. Administration of dietary supplemental cadmium to pigs resulted in an upward tendency of relative weight of immune organs, whereas CdAA supplement can increase relative weight of immune organs. Among four groups, there was no significance between Tl and control or between T2 and T3. As far as Ig in serum was concerned, there was a downward tendency from groups added with cadmium. CdAA increase Ig level clearly. Compared with T3, serum IgA and IgM levels of T2 increased 5.6% (P<0.05), 15.1% (P<0.05) respectively.The analysis of serum biochemical parameters indicated that there was an upward tendency, as far as GOT and GPT in T2 and T3 was concerned. Compared with T3, GOT and GPT activities of T2 decreased by 7.9% (P<0.05) ,18.7% (P<0.01) respectively. There was no significance between T2 and control or between Tl and control (P>0.05, P>0.9 respectively). There was a downward tendency, as far as ALPof treatments supplement cadmium was concerned. Compared with T3, ALP level of T2 increased by 25.9% (P<0.05). There was no significance between T2 and control or between Tl and control (P>0.05, P>0.05 respectively). As far as serum TP, ALM, SUN levels was concerned, there was no significance among four groups (P>0.05), but there was a downward tendency from treatments added with cadmium and T3 was the lowest. There was no significance for serum CH...
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