Study On Pharmacokinetics Of Tilmicosin At A Single Oral Dose In Chickens Of Blood Stagnation Syndrome

The Blood Stagnation Syndrome model was made in chickens through Muscular administration of E.colli endotoxin to them. To study pharmacokinetics of tilmicosin in chickens of Blood Stagnation Syndrome in at a single oral dose of 20mg/kg , the investigation included three groups, that is to say, the healthy, Blood Stagnation Syndrome and contrary Syndrome group; the drug concentrationin in plasma was done in microorganism-test way, Calculation of pharmacokinetical parameters was performed using 3P87 PK programe. The results indicated:(l) the data of the drug concentration-time in the two groups of the Healthy group, XuYuZhuFu contrary-syndrome decoction group were fitted to a two- compartment model with first-order absorption. The main PK-Parameters of the healthy group and XueYuZhuFu decoction contrary-syndrome group were T1/2 a (0.662 0.354)h ,T1/2 3 (36.344+ 15.204)h,Kl/2a (0.340+ 0.132)h,V/F (7.049+4.320)L/kg,Cmax( 1.108 + 0.523) mg/L,Tp( 0.765+ 0.163)h,CL (0.571+0.138) Lh/kgh,AUC(56.220?1.933)mg.h/L and T,/2a(3.655 + 2.470)h,T1/2β为( (45.576+14.201) h,K,/2a(0.142+ 0.101)h,V/F (20.246 + 9.416)L/kg Cmax (1.405 + 0.332) mg/L,Tp (1.011 + 0.534)h,CL (0.484 + 0.113) L/kgh,AUC (59.250 + 36.160)mg.h/L respectively.(2)The drug absorbtion course in XuYuYhuFu syndrome group was no orderliness, the blood drug concentration was quite slow and the concentration-time data couldn't be calculated by PK programe. (3) XueYuZhuFu decoction could better the hemorheology induced by E.colli endotoxin,Further more, the pharmacokinetics traracteristics of a single oral dose of tilmicosin in the Blood Stagnation group.