The Study On Toxicology Of CF With Mice

In order to clarify the limited and safety of the toxicology experiment which include acute, accumulation, special, sub-acute toxicity, traditional teratogenic ,mutagenic test with Kunming mice.Except the acute and the accumulation toxicity text ?the other tests included one control group and three test groups which were added 1%, 2%, 3%bentonite respectively on the base of the ordinary diets.The acute the tast indicated that , LD50 was over 55. 024g/kg which inferred that bentenite is nonpoisonous mtter . The result of accumulation test did not show death and anomaly phenomena. The results suggested that CF was impoisonous material. The result of the spern anomaly test indicated that different among the groups were not signifinant. the result of the spern anomaly test indicated that different between the 3%group test group test control group the control group was insignificant.The subchronic toxicity test of CF in Kunming mice was studied:The mice was examined for whole blood, serum glutamicpyruvic, glutamicoxaloacetic , and illness state or heart, liver, spleen, lung, kidney, brain at 30 and 90 days after drug administration .The results suggested that the mice high dose, middle dose and low dose have not manifested toxicity. The toxicity CF was very slight; The breeding test The mice was examined for living numbers of boring young, young rat growth; birth living rate and foster-living rate. The result indicated that CF were not signifinant toxicity matter.The teratogeny test indicated that the embryo weight; body lendth and tail length of negative group was not signfinantly highter than those of control group. The different was not signifinant in tai bone; appearance anomaly; internal organs anomaly.The mutagenic test indicated that Micronucleus, Sperm abnormality, Ames test result is negatative. The result indicated that CF were not signifinant mutagenic matter.