| At present, pesticide are widely used to control pests or diseases on medicinal plants. But there is no one kind of pesticide is registered on medicinal plants. How about its effects on the quality of Traditional Chinese Medicinal materials? How about its safety? There is no answer. So this paper mainly deals with the above questions. Three kinds of medicinal plants are chosed: Ephedra sinica Stapf, Lycium barbarum L., Lonicera japonica Thunb. Their common pests are aphides. As a low poisonous pesticide imidacloprid is widely used in many areas where medicinal plants are planted. The main work is as follows:1 , Prevention and cure effect experiment of imidacloprid on Lycium barbarum L., Lonicera japonica Thunb was carried out. And the comparison was also done between imidacloprid and other local pesticides which usually were highly poisonous.2, Upon the field experiment, the primary study on the effects of imidacloprid on the three medicinal materials' index components was carried out. The main methods were HPLC and Spectrophotometry.3, Two HPLC methods for imidacloprid residue were established and the dynamics of imidacloprid residue and degradation in Ephedra sinica Stapf, Lycium barbarum L., Lonicera japonica Thunb and soil was analysed.The detailed results obtained are as follows:1 , The prevention and cure effect experiment indicated that the effect was above 80% after spraying one day, above 96% after 5 days, and its effective time was much longer. Compared with other local pesticides, it has several traits, such as safe, more effective and economical.2, Imidacloprid had some effects on the content of chlorogenic acid in Flos lonicerae and ephedrine in Ephedra sinica. And with the concentration increasing, the effects were more evident. Imidacloprid had little effect on the content of lycium barbarum polysaccharide in Fructus lycii.3, The results of residual experiment indicated that the half life of imidacloprid...
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