Study On Chemical Constituents

Rhizoma arisaematis is from the Arisaema erubescens (Wall.) Schott, A heterophyllum B.L. or A. amurense Maxim.’s dried tuber,with removing dampness to reduce phlegm, relieving rheumatic pain improving detumescence and other effects, attending stubborn phlegm,cough, swelling dizziness, stroke, ficial paralysis, epilepsy and tetanus, topical treatmenting swollen boils, tuberculosis, snake bites. Arisaema wide distribution, resources are very rich, while TNS reported good antitumor effect, but the material basis of its anti-tumor effect is unclear, the study of the chemical constituents of Arisaema a more systematic and studies substances.Through the use of silica gel column chromatography, RP (RP-18) columnchromatography,Sephadex(SephadexLH-20)column chromatography, MCI gel CHP 20P, and other semi-preparative HPLC separation of material and separation technology, combined with modern spectroscopic Analysis, isolated from the lungs through the grass 35,23 compounds were identified. Which areβ-sitosterol (1), daucosterol (2), (3S)-(—)-3-Hydroxybutanolide(3),3,4-dihydroxybenzoic(4),4-hydroxybe nzoic acid(5),5-(hydroxymathyl)furan-2-carbaldehyde(6), nocotinamide (7),5-hydroxy-2-hydroxymethyl pyridine(8),Ribose nucleosid(9), Uridine(10),Thymidine(11),sachaliside(12),glucose ester of (E)-ferulic acid(13),Evergreenglycosides(14),3-(4-Hydroxy-3-methoxyphenyl)propy 1-β-D-glucopyranoside(15),AitchisonidesB(16),(—)-phaseicacid(17),(6R, 9R)-3-oxo-α-ionolβ-D-glucopyranoside(18),roseoside(Ⅱ)(19),(9S),(12S), (13S)-Trihydroxy-10(E)-octadecenoicacid(20),(9S),(12R),(13S)-Trihydro xyoctadeca-10(E),15(Z)-dienoicacid(21),(9S,12S,13S,)-2,3-dihydroxypro pyl9,12,13-trihydroxyoctadec-10(E)-anoate (22), acortatarin A(23)。The structure of the type involved in sesquiterpene, single quote, fatty acids, benzene derivatives and structure of the type of steroid. Of which 19 compounds were first isolated from this plant are. Nicotinamide combined with carbogen treatments in locally bladder cancer; pine glycosides and sachaliside to inhibit suppression of tumor necrosis factor-a production. Therefore, this paper reveals the initial anti-tumor effect of Arisaema material basis for the further development and utilization of resources, TNS provides a scientific basis.