Study On The Secondary Development

Lemai particles is developed based on the theory of traditional Chinese medicine treatment of acute and chronic cardiovascular and cerebrovascular diseases, a new class of pure Chinese medicine granules by salvia root, red peony root, safflower made seven herbs, herbs as Salvia, minister drugs as root, red peony, safflower. With qi and blood circulation, circulation tongmai efficacy of commonly used in blood stasis due to headache, dizziness, chest pain, palpitations, angina, coronary heart disease, the treatment of multiple cerebral infarction. Currently, the clinical use of proprietary Chinese medicines Lemai parties have granules, tablets, pills, capsules, granules, which is exclusive varieties Sichuan Huaxi Pharmaceutical Company Limited.Cardiovascular and cerebrovascular diseases, diseases of the circulatory system, also known as the high incidence of the disease in modern society a great threat to human health. Sichuan Huaxi Pharmaceutical Lemai particles developed for cardiovascular disease a significant effect, as a new class of medicine granules with broad development and research value. But representatives Lemai preparations Lemai particles in the chemical composition index single foundation unclear efficacy, taking large doses, does not dissolve completely. In response to these problems, the subject Lemai particles for further research and development.ObjectiveThis study was designed from the start with the material basis of efficacy Lemai particles index components to obtain information, to optimize the process, the development of a new generation of products, improve quality and standards-related drugs, including particles including Lemai product quality and market competitiveness.MethodsChemical composition of the particles Lemai study:Combining TOF-MS and standard control method, identification Lemai granules in chemical composition.Research Lemai effervescent technology:the single factor test, orthogonal design, combined with the quality of the evaluation, stability study and optimize the effervescent technology.Quality Standards Lemai effervescent:HPLC Determination Lemai effervescent in four main active ingredient, and to establish the efficacy of effervescent component Lemai fingerprints to conduct a comprehensive evaluation of their quality and control.ResultsUsing TOF-MS method identified23chemical composition, standard control method identified16index components.Using TOF-MS method identified23chemical composition, standard control method identified16index components.Atlas establish Lemai effervescent fingerprints and determination method, and can play on the effervescent quality evaluation and control. ConclusionFirst, the efficacy Lemai particulate material basis of clear and identified23compounds,19index components to get the information. Secondly, the process of establishing Lemai effervescent tablets, effervescent tablets disintegrate rapidly, rapid onset, and finally establish Lemai effervescent HPLC method for the determination of their fingerprint to control the quality of the preparation and evaluation.