Study On The Risk Factors Of Vascular Cognitive Impairment

Purpose:Based on the patients of ischemic cerebrovascular disease, analyze the influence factors of Vascular cognitive impairment with no dementia(VCI-ND), to provide evidence prevention of Vascular cognitive impairment (VCI).Object and methods:There were 108 subjects (age 40-80 years old) from Dong zhi men Hospital Beijing university of Chinese medicine who were accepted an exam neuropsychological assessments,compare magnetic resonance imaging (MRI) and the standard diagnosis of the Vascular cognitive impairment, the Mini-mental state examination(MMSE) confirmed VCI patientthe Hachinski Ischemia Seale (HIS), the Hamilton Depression scale (HAMD) and the Hamilton Anxiety scale (HAMD) were used for differential diagnosis,The United States institute of health stroke scale (NIHSS),MRS were used to access ischemic cerebral apoplexy sequelae, the Clinic Dementia Rating(CDR), the Clock Drawing Test(CDT),TXT,the Ability of Daily Living (IADL) scale,PSMS and so on were used to access the global cognitive function.According to the results,we selected vascular mild cognitive impairment of 54 cases (VCI-ND group) and cognitive function in normal group of 54 cases (NC group), and distinguished the patients with ischemic stroke TOAST classification and OCSP classification.Using case-control study, analyze general information(sex,age,profession),living habits (smoking, drinking), family history of disease, illness,the recent ischemic stroke onset and duration of symptoms and so on in two groups of patients, and doing statistical analysis with SPSS 19.0 software. According to the data type using statistical description, x 2 test, t test, rank and inspection and so on. Inspection level for a=0.05 and a=0.01.Results:1.General information:(1) age(P=0.325> 0.05), sex(P=0.537> 0.05), occupation(P=0.051 > 0.05):there was no statistically significant differences between the two groups. (2) the level of education (P=0.002< 0.05):two groups of education degree difference was statistically significant. The longer the education of susceptibility rate is lower, tend to be more low education group vascular mild cognitive impairment.2.Life habits:smoking (P=0.699> 0.05), drinking (P=0.243> 0.05), head trauma (P=0.808 > 0.05):there was no statistically significant differences between the two groups.3.family history:(1) the family history of hypertension (P=0.048< 0.05), the family history of dementia (P=0.015< 0.05),the difference was statistically significant, hypertension family history can increase 2.205 times the risk of vascular mild cognitive impairment, family history of dementia increased 9.217 times the risk of vascular mild cognitive impairment.(2) the family history of stroke (P=0.843> 0.05), the family history of coronary heart disease (P=0.505> 0.05), the family history of diabetes (P=0.606> 0.05), there was no statistically significant difference.4.Disease:coronary heart disease (CHD) (P=0.832> 0.05), diabetes (P=0.552> 0.05), hypertension (P=0.839> 0.05), hyperlipidemia (P=0.847> 0.05), there was no statistically significant difference in the two groups.5.ischemic stroke:(1) TOAST classification(P=0.412> 0.05)and OCSP classification (P=0.715> 0.05):there was no statistically significant differences between the two groups.(2)Number of ischemic stroke (P=0.264> 0.05),the duration of symptoms(P=0.230 > 0.05),there was no statistically significant difference frequency in two group. (3) the symptoms:in sudden physical activities(P=0.332> 0.05), speech against adverse(P=0.053> 0.05), comes(P=0.481> 0.05), difficulty swallowing(P=0.588> 0.05), not clear vision (P=0.152> 0.05),sudden feeling numb(P=0.687> 0.05),there was no statistically significant difference.Conclusion:1.vascular mild cognitive impairment tend to be more the elderly and low education group, high education level for the protection of the VCI factors.2.hypertension family history can increase 2.205 times the risk of vascular mild cognitive impairment, family history of dementia increased 9.217 times the risk of vascular mild cognitive impairment,both are the risk factors of VCI.