| SourceThe subject came from the pharmaceutical industry in research projects, "Chinese medic-ine research prevention and treatment of chronic diseases Community management" project, project of number 201207012.ObjectiveSummary type 2 diabetes (T2DM) combining with different macrovascular disease syn-dromes distribution characteristics, providing an initial reference for Integrative Medicine dia-gnosis and treatment.MethodsThe premise of the study was a combination of diseases and syndromes, T2DM with macrovascular disease charged a total of 931 cases. Group A (type 2 diabetes+hypertension+ CHD) had 579 cases; group B (type 2 diabetes+hypertension+stroke group) had 124 cases; group C (type 2 diabetes+hypertension, coronary heart disease+stroke group) had 228cases. Application of cross-sectional survey data, statistical analysis of patients with general inform-ation, TCM syndromes and laboratory indexes. TCM syndromes included yin jin loss, qi deficiency of spleen, deficiency of qi and yin, deficiency of yin and yang, gastrointestinal hot, damp spleen, liver swelter, hyperactivity, qi stagnation, phlegm block, blood stasis 11 syndromes, syndromes demonstrated by Expert Group. Laboratory parameters included serum creatinine (SCr), uric acid (UA), fasting plasma glucose (FPG), triglyceride(TG), high density lipoprotein(HDL-c), low-density lipoprotein (LDL-c),cholesterol (TC) for statistical analysis via biochemical analyzer of The Dong zhi men Hospital. Analysis of the main syndromes occurrence rate differences by Chi-square test. Via T-test, ANOVA and non-parametric tests, analysis of the differences between laboratory parameters A, B, C groups; analysis of the same syndromes of laboratory parameters among A, B, C groups difference; TG, HDL-c, LDL-c, TC level of different syndromes differences in each group, laboratory parameters and fasting plasma glucose level within each group by Correlation analysis.Resultsl.The regular pattern of syndromes occurrence in the group:The occurrence rate of deficiency in group A was:deficiency of qi and yin>yin jin loss syndrome>deficiency of yin and yang(p<0.01). The occurrence rate of empirical, phlegm block, blood stasis were higher than damp spleen syndrome (p<0.05), the occurrence rate of phlegm block and blood stasis had no difference.The occurrence rate of deficiency in group B was:deficiency of qi and yin> yin jin loss syndrome (p<0.05). the occurrence rate of empirical, phlegm block card, blood stasis, damp spleen syndrome had no difference.The occurrence rate of deficiency in group C was:deficiency of qi and yin> yin jin loss Syndrome (p<0.05); the occurrence rate of empirical, phlegm stasis syndrome>damp spleen syndrome (p<0.01), the occurrence rate of phlegm block and blood stasis had no difference.Dificiency of qi and yin, yin jin loss syndrome, phlegm stasis syndrome, blood stasis syndrome, hyperactivity syndrome, damp spleen syndrome among group A, B and C, comparison of occurrence rate (p> 0.05), the difference was not statistically significant.2.Laboratory parameters of A, B, C groups:A, B, C groups, SCr levels of group B was higher than group A (p<0.05), LDL-c level of group B was higher than group C (p<0.05), TC level of group B>group A>group C (p<0.05), the difference was statistically significant.3.The same syndrome type laboratory parameters in A, B, C groups compareDeficiency of qi and yin:SCr levels of group B was higher than that in group A and group C (p<0.05), no difference between group A and group C;Phlegm stasis syndrome:TC level of group B was higher than that in group A and group C (p<0.05);Heat spleen syndrome:TC level of group B was higher than that in group A and group C (p<0.05).4.Different syndrome types of TG, HDL-c, LDL-c, TC of in each group compare:Patients of Group A and Group C with phlegm stasis syndrome, blood stasis syndrome, hyperactivity syndrome showed no difference on lipid level (p>0.05). Patients of Group B TG levels with liver yang lower than phlegm stasis syndrome, blood stasis syndrome, damp spleen syndrome (p<0.05), statistically significant. HDL-c, LDL-c, TC level phlegm stasis syndrome, blood stasis syndrome, hyperactivity syndrome, damp spleen syndrome three cards no difference (p> 0.05).5.The correlation between laboratory parameters and fasting glucose levels of each group:Each group of SCr, UA, TG, HDL-c, LDL-c, TC and fasting plasma glucose level showed no significant correlation.Conclusions1.Deficiency of qi and yin accounted for in A, B, C groups of the deficiency in a dominant position, which higher than yin jin deficiency; the Standard of empirical, phlegm block, blood stasis were higher than heat spleen syndrome (p<0.05) of group A, while group C, occurrence rate of phlegm stasis syndrome> damp spleen syndrome.2.SCr level of group B was higher than group A, LDL-c level of group B was higher than group C, TC level group B>group A>group C, suggesting that the combined stroke complications, the occurrence of kidney disease risk was increased.3. Patients of group B should pay close attention to serum creatinine and blood lipid levels, kidney function should regularly reviewed and strictly control blood lipid levels.4. TG level of hyperactivity syndrome was lower than phlegm stasis syndrome, blood stasis syndrome and damp spleen syndrome in Group B, probably because it is a transitional Stage of the development that we should pay attention to this period.5. Each group of SCr, UA, TG, HDL-c, LDL-c, TC and fasting plasma glucose level shown no significant correlation. |
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