Effects Of Traditional Chinese Medicine On Macro Vascular Disease And The Stayus Of Oxidative Stress In Patients With Type 2 Diabetes Mellitus In Early Stage

Objective To observation the influence of Six Drugs Containing Romania Preparation（SDCRP） and Tablet of ginkgo Leaf on the status of oxidative stress in subjects with type 2 diabetes of Yin Deficiency and Carotid internal medial thickness（IMT）.Methods The study was an 18-month double-blind,randomized,parallel controlled add-on trial.A total of 108 subjects with diagnosed in type 2 diabetes with previous treatment of hypoglycemic agents in early stage were recruited,whose differentiation is deficiency of kidney yin type,accompanied by internal heat and stagnation.They were randomized into two groups,one group receiving SDCRP and Tablet of ginkgo Leaf while the other group receiving placebo.87 subjects completed the trial,43 received SDCRP and Tablet of ginkgo Leaf and 44 received placebo.There was 56 patients whose right IMT thicker in the first 18 months than before treatment taken into the research with Chinese Medicines group 25 cases（17 male,8 female）,while the control group,31 patients（18 men, 13 women）.Observation:①Glucose Metabolism:FBG,PBG,HbA_1C;②Lipid Metabolism:TC,TG,HDL-C,LDL-C,FFA;③SOD,MDA;④Carotid intinal medial thickness（IMT）were also measured.After 6 month follow-up,the above profiles were repeated after cessation of medication.Results①There were significant increase in FBG、PBG and HbA_1C in control group（P＜0.05 or P＜0.01）.There were increase in FBG and HbA_1C,reduced in Chinese Medicines group.②There were increase in TG in both groups,and the increase was significiant in control group（P＜0.05）.There was increase in FFA in control group,while reduced in Chinese Medicines group（P＞0.05）.③Compared between groups before and after treatment,there were significant increase in IMT in both group（P＜0.01）.The obviously thickening rate was 52.00%in Chinese Medicines group,while 64.52%in control group.It was shown significiant difference between the two groups（P＜0.05）. There was 12.52%decline in the obviously thickening rate and 19.4%decline in the relative risk in Chinese Medicines group.After the third stage of the treatment,SOD,MDA bwere significantly increased in both group（P＜0.05,P＜0.01）,and IMT has no obvious correlation with SOD and MDA in the 18th month（P＞0.05）.Conclusions①It is showed a tendency that SDCRP and Tablet of ginkgo Leaf can retard the rising of TG、TC、LDL-C and FFA.②It is showed a tendency that SDCRP and Tablet of ginkgo Leaf can retard the thickening of Carotid intinal medial thickness and reduce the occurrence of AS.③Oxidative stress increases in type 2 diabetes in early stage.