Clinical Observation On Treatment Of Chronic Kidney Disease With "Damp - Heat"

Chronic kidney disease is a refractory disease in the world recognized. The late professor Zhao Shaoqin of Beijing University of Chinese Medicine for the study of chronic kidney disease in modern medicine thoroughly, and established a set of integrated treatment for clinical diagnosis and treatment of chronic kidney disease. Professor Qiu Moyan according to Zhao clinical experience put forward the concept of "shi re shang xue", to summarize the development process of damp heat syndrome of blood heat, blood stasis pathogenesis, and applied to the treatment of chronic kidney disease.[Content] this thesis is divided into two parts:literature review and clinical research. Through literature study, summary and Analysis on the academic thoughts of Professor Zhao Shaoqinin treatment of chronic kidney disease and inheritance from the perspective of damp heat, and the clinical application of "Damp heat injury blood mentor Qiu Moyan" thought of diagnosis and treatment of chronic kidney disease stage 2-3 in 30 cases were summarized.Literature review:Zhao Shaoqin academic research and development progress in treatment of chronic kidney disease from the perspective of damp heat.This literature discusses the treatment of chronic kidney disease from Zhao classic ideas, clinical experience and experimental research on verification etc. A detailed analysis of the 5 views of Zhao in the treatment of chronic kidney disease: chronic kidney disease is not a simple weak disease; diet protein in chronic kidney disease; excercises in chronic kidney disease; the chronic kidney disease may be an inherited; theory of chronic renal function can be reversible, and summarized the treatment of edema and hematuria, and the use of Chinese medicine treatment of uremic symptom experience. At the same time, the inheritance of Zhao’s academic thoughts, including his disciples, other scholars on Zhao’s academic thoughts summarize and inherit their application, and through the experimental study based on modern Zhao academic thought and experience for further research.Clinical research:To observe the clinical efficacy of "shi re shang xue" in treating stage 2-3 chronic kidney disease.[Objective] through the observation of patients before and after treatment of TCM syndrome integral and the changes of renal function, summarize the clinical experience of tutor from "shi re shang xue" in treating stage 2-3 chronic kidney disease. [Method] with the western medicine diagnosis standard into stage 2-3 chronic kidney disease and TCM syndrome differentiation of 30 cases of damp heat syndrome in patients with trauma, on the basis of Western medicine treatment, treated by TCM treatment, treatment for 12 months. Observed before treatment, the changes of clinical symptoms and renal function of 6 months,12 months of treatment. [Results] the clinical total curative effect:6 cases were markedly effective, effective in 20%, effective in 11 cases, efficiency 36.67%,8 cases of stable, the stable rate 26.67%, invalid 5 cases, efficiency 16.67%. The total effective rate was 83.33%.The efficacy of TCM syndrome:2 cases were cured,4 cases markedly effective, effective 24 cases, invalid in 0 cases. The total effective rate was 100%. Treatment for 6 months, and the total score before treatment than the difference was statistically significant (P< 0.05);treatment for 12 months, and the total score before treatment than the difference was statistically significant (P <0.05). In the specific symptoms, treatment for 6 months with those before treatment, body weight drowsiness, nausea and vomiting, pain, edema, dark complexion, throat swelling and pain, yellow urine disease was statistically significant(P< 0.05). Nausea and vomiting, drowsiness, dry mouth, bitter taste in the mouth and body weight, complexion dark and gloomy, edema, sore throat, yellow urine before treatment and after treatment for 12 months, the difference was statistically significant (P<0.05). Secondary symptoms, abdominal distension, mouth sticky, skin armour fault treatment for 6 months,12 months before the treatment and the difference was statistically significant (P< 0.05). Limb numbness in 12 months of treatment compared with that before treatment, there was statistically significant difference (P<0.05). The symptoms of thirst without desire to drink for 6 months compared with that before treatment, there was statistically significant difference (P<0.05). The indexes of renal function: reducing the treatment for 6 months, Scr compared with those before treatment, the difference was statistically significant (P<0.05); 12 months of treatment, Scr decreased compared with those before treatment, the difference was statistically significant (P<0.05); treatment of 12 months compared with 6 months of treatment with Scr decreased, the difference was statistically significant (P<0.05). 6 months of treatment, BUN decreased compared with those before treatment, the difference was statistically significant (P<0.05); 12 months of treatment, BUN decreased compared with those before treatment, the difference was statistically significant (P<0.05); treatment of 12 months compared with 6 months of treatment with BUN increased, the difference was not statistically significant (P> 0.05).6 months of treatment eGFR were increased compared with before treatment, the difference was statistically significant (P<0.05); 12 months of treatment eGFR were increased compared with before treatment, the difference was statistically significant (P<0.05); treatment of 12 months compared with 6 months of treatment with eGFR increased, the difference was statistically significant (P<0.05). [Conclusion] from "shi re shang xue" in treating stage 2-3 chronic kidney disease, combined with the basic treatment of Western medicine, can improve the clinical symptoms, renal function, delay the progression of chronic renal insufficiency.