Clinical Study On The Therapeutic Effect And Quality Of Life Of Bushen Shugan Anshen Prescription In Treating Menopausal Syndrome

Background:With the complexity of the clinical symptoms and high incidence in Menopausal women population, Menopausal Syndrome has a great impact on the physical health and mental health of the patients. At the same time, the disease in varying degrees, reduces their quality of life. As people’s living standards rise and Menopausal women population continues to increase, how to prevent and treat Menopausal Syndrome, at the same time improve the patients quality of life, becoming an important research task in medical science. Hormone replacement therapy(HRT) is the preferred choice for the prevention and treatment of its western medicine therapy, but in the process of treatment increased endometrial cancer and the risk of diseases such as heart diseases, blood clots, making its application by certain restrictions. At present, the traditional Chinese medicine as a hormone therapy for the treatment of the disease has great advantages, having relatively wide research prospects. But at the moment, in the vast majority of the clinical curative effect of traditional Chinese medicine treatment of Menopausal Syndrome evaluation, without life quality evaluation information, making it lack of objectivity and standards. My tutor professor k. wang, has many years of experience in the cl ini cal treatment of this disease. In terms of pathogenesis, she thought kidney empty is fundamental, and attached importance to the pathogenesis of liver depression and mind losing guardian. In treatment, she developed a Chinese medicine prescription, named as Bushen Shugan Anshen Decoction, with clinical curative effect. Currently, in foreign countries, Menopause Specific Quality of Life Score Table (MENQOL) which is reliable and effectively is often used to evaluate the therapeutic effect of Menopausal Syndrome. In this study, we not only used the MENQOL to evaluate the patients’life quality, but also used the traditional clinical efficacy evaluation indicators, making the curative effect evaluation of Bushen Shugan Anshen Decoction of the present study more objective and standardized. This research was of great significant to Menopausal Syndrome.Objective:Observe the curative effect of Bushen Shugan Anshen Decoction of Menopausal Syndrome. Evaluate its effectiveness in eliminating clinical symptoms and improving the quality of survival, providing scientific basis for its clinical application. And discuss its mechanism, providing a reference for the Chinese medicine treatment.Methods:Using random method,60 cases of Menopausal Syndrome were divided into treatment group and control group, each of 30 cases. The treatment group was given Bushen Shugan Anshen Decoction, and the control group was given Kunbao pills. All medication for 8 weeks. MENQOL score, modified TCM symptoms score and Kupperman score should be separately recorded before and after the treatment, as indicators of efficacy evaluation. All data analysised by SPSS 20.0 statistical software. All the hypothesis test adopt bilateral inspection, P<0.05,the difference was statistically significant.Results:1. The contrast of overall effect:The total effectiveness of Bushen Shugan Anshen Decoction group was 96.67%, while it was 80.00%in Kunbao pills group. The effect of the Bushen Shugan Anshen Decoction group was better than the control group, there were significant differences (P<0.05).2. The degree of illness:After treatment, Bushen Shugan Anshen Decoction group had 24 cases of mild,6 cases of moderate,0 cases of severe; Control group had 20 cases of mild,8 cases of moderate,2 cases of severe. Differences between the two groups were statistically significant (P<0.05).3.Improved Kupperman score:Improved Kupperman score in Bushen Shugan Anshen Decoction group and Kunbao pills group after treatment of integral were significantly decline, the score in treatment group improved better than that of control group,and the difference was statistically significant (P <0.05).4. TCM syndrome score:TCM syndrome score of two groups after treatment were significantly lower, the score in Bushen Shugan Anshen Decoction group was superior to that in the control group, and the difference was statistically significant (P<0.05).5. A single TCM symptoms analysis:Treatment group in hong sweat out, insomnia, much dream, heart palpitations, shortness of breath, beind agitated depression and five upset hot changed significantly better than that of control group (P<0.05).6.The MENQOL analysis:Comparing the grade between pretreatment and posttreatment, the grade in the domain of vasomotion, psycology, physiology and sex reduced after treatment by Bushen Shugan Anshen Decoction group and control group (P<0.05). Comparing the grade changes of pretreatment and posttreatment between Bushen Shugan Anshen Decoction group and control group, The effect of the Bushen Shugan Anshen Decoction group was better than the control group in physiology domain (P<0.05).7. Security:Two groups of patients during the drug did not appear allergic reaction and other symptoms. The monitoring indicators were not seen obvious anomalies.Conclusions:1.The effect of Bushen Shugan Anshen Decoction was excellent and safe, which could be worth promoting in clinical use to the Menopausal Syndrome. TCM syndrome coul be improved, specially in hong sweat out, insomnia, much dream, heart palpitations, shortness of breath, beind agitated depression and five upset hot. At the same timd quality of life were improved, specially in physiology domain.2. Quality of Life could be used to evaluate the therapeutic effect of traditional Chinese medicine treatment of Menopausal Syndrome, and was worth promoting.