Clinical Study On Treatment Of Arteriosclerosis Obliterans With

Objective:Through the comparison on the basis of conventional therapy, treatment of arteriosclerosis patients in treatment group were treated with Jiedu Tongmai Decoction and the control occlusion (Atherosclerosis Obliterans, ASO), the degree of improvement in clinical effect in patients with laboratory indexes and clinical symptoms, clinical curative effect of the Decoction in the treatment of this disease, and the the mechanism is discussed.Methods:Patients were selected from Dongzhimen hospital in accordance with the inclusion of peripheral vascular atherosclerosis obliterans of statistical criteria 53 patients were randomly divided into 25 cases of the control group (conventional drugs, lipid-lowering, anti platelet therapy:atorvastatin alcium tablets, thanks to Aspirin Enteric-coated Tablets, with complications symptomatic hypoglycemic, antihypertensive treatment to); 28 cases in the treatment group, on the basis of the control group given Jiedu Tongmai granule,8 weeks as a course of treatment. The completion of a course of treatment, observation and detection of the following indicators.To observe the general condition of the patient, comprehensive score of lower limb skin temperature, pain, numbness, intermittent claudication etc.The measurement of ankle brachial index (ABI);The detection of fasting venous blood samples were measured triglyceride TG total cholesterol TC, high density lipoprotein,low density lipoprotein LDL HDL;The serum levels of tumor necrosis factor-a measured by radioimmunoassay (TNF-a) and interleukin-6 (IL-6),interleukin-10 (IL-10), adiponectin (APN). Results:Jiedu Tongmai Decoction in the treatment of arteriosclerosis obliterans of the total effective rate was 84.21%, control group total effective rate was 42.42%, the treatment group was significantly better than the control group (P<0.01), with a significant difference.Clinical symptoms:treatment group and control group was compared before and after the treatment.patients with limb pain,cold,numbness,intermittent claudication distance,the clinical symptoms were obviously improved,the treatment group was significantly better than the control group (P<0.01),wifh a significant difference.The ankle brachial index (ABI):ABI control group before and after treatment there was no significant difference (P>0.05), there was statistical significance between the treatment group before and after treatment (ABI P<0.05), the treatment group had significant difference compared with the control group (ABI P<0.05).Blood lipid indexes:self contrast was significantly improved in two groups before treatment and after treatment, compared between the two groups, the treatment group than the control group in reducing TC,TG,LDL,increase HDL (P<0.05), the difference was statistically significant.Inflammatory factors:before and after treatment in the two groups were compared with IL-6, were decreased, with significant difference (P<0.01), and the treatment group and the control group, decreased significantly (P<0.01), with a significant difference. TNF-a treatment group before and after treatment compared, decreased significantly, with significant difference (P<0.01), the control group before and after treatment comparison, the difference was not statistically significant (P>0.05). Before and after treatment in patients with IL-10 compared with themselves, have increased, with a significant difference (P<0.01), and the treatment group and the control group, increased significantly (P<0.01), with a significant difference. Before and after treatment in patients with APN compared with themselves, have increased, with the difference (P<0.05); and the treatment group and the control group, increased significantly (P<0.05), the difference was statistically significant.Conclusion:Compared with the control group with routine aspirin enteric coated tablets of antiplatelet therapy, plus Jiedu Tongmai decocting free Chinese medicine granule in the treatment of ASO, can effectively reduce the patients with limb cold, numb, pain and other symptoms; can effectively improve the limb ABI; can promote reduced blood TC, TG, LDL, HDL increased; to promote the reduction of TNF-alpha, IL-6, IL-10, APN increased; the clinical curative effect of Jiedu Tongmai Decoction in the treatment of ASO significantly, and its mechanism may be related to improving blood hypercoagulable state, anti platelet aggregation, prevent thrombosis; inhibition of inflammation, promote vascular intimal injury and repair; improve immunity.