Clinical Study On Treatment Of Ulcerative Colitis With Changyankang Granule

Purpose:To observe the clinical effect of Changyankang granules in treatment of patients with ulcerative colitis,and as the intervention,patients with intestinal mucosa ICAM-1,MMP-9,,explore the possible mechanisms of traditional Chinese medicine treatment of ulcerative colitis.Methods:Collected 60 cases of patientsin who diagnosed with ulcerative colitis in shenyang military region general hospital outpatient service in January 2013 and January 2014.60 cases were randomly divided into two groups:traditional medicine group(because of poor compliance off 2 cases during the treatment)、western medicine group,the differences in age,sex,disease in patients with no statistical significance((P>0.05).Bfore the treatment,patients were clamped lesions through colonoscopy in the lesion of most obvious period of mucosal ulcer edge or hyperemia and edema place,and embedded in paraffin.Chinese medicine treatment group treated with Changyankang,100ml/time,2 times/day.Western medicine treatment group treated with mesalazine(Ai disha),1g/time,4 times/day.The treatment time was 8 weeks.After the treatment,patients were clamped lesions through colonoscopy in the lesion of most obvious period of mucosal ulcer edge or hyperemia and edema place again,and embedded in paraffin.Usig immunohistochemical staining detected in patients with treatment of 58 cases of intestinal mucosal specimens befor and after.Observeing the clinical efficacy and expression of two groups.Results: 1The two groups were obviously improved than before in main clinical symptoms,the clinical feefective rate is high.Cmopared with the traditional Chinese medicine group and western medicine group,the difference was statisticallysignificangt(P<0.05).Colonic mucosal lesions were obviously improved,intestinal mucosal hyperemia,edema,erosion,ulcer has the varying degree better,Chinese medicine treatment group colon tissue recovery better,but no statistically significangt(P>0.05).The comprehensive curative effect score decreased significantly,the Chinese medicine group is better,but the difference was no statistically significangt(P>0.05). 2Before the treatment in patients with ulcerative colitis,the expression of ICAM-1,MMP-9,P-gp were increased,decreased significantly after treatment,the difference was statistically significangt(P<0.05),But no statistically significangt between groups(P>0.05).Two groups were no obvious adverse reactions.Conclusion:Changyangkang and mesalazine were better treatment of active UC patients,and the possible mechanism might be related to the down-regulation of ICAM-1、MMP-9、P-gp expression.