Study On Distribution Of TCM Syndromes In Patients With Active Ankylosing Spondylitis

Purpose: Ankylosing spondylitis(AS) is a seronegative disease that mainly be invasion of sacroiliac joint, joint axis and extremity joint, which also can affect internal organs and other tissues.At present,the causes of AS is still not clear, mechanism is still unkown. There is no unified standard for Traditional Chinese medicine to diagnose AS. This research according to "clinical observation combined with practical guiding principles of clinical research on new drugs of traditional Chinese medicine for treating Bi syndrome",the period of activity of AS is divided into the following 5 kinds of cards: kidney deficiency and cold syndrome, kidney deficiency and blood stasis, cold dampness syndrome, damp heat stagnation syndrome, deficiency of liver and kidney, and explore the pathogenesis of AS and the ratio of male to female patients, syndrome distribution, renal deficiency and cold syndrome and deficiency of kidney and blood stasis syndrome.Material and method:In the Department of rheumatism of Liaoning University of Traditional Chinese Medicine collected AS patients 118 cases, according to the " Clinical observation combined with practical guiding principles of clinical research on new drugs of traditional Chinese medicine for treating Bi syndrome ",which is divided into the following 5 types: kidney deficiency and cold syndrome, kidney deficiency and blood stasis, cold dampness syndrome, damp heat stagnation syndrome, deficiency of liver and kidney. Using SPSS17.0 statistical software to establish database and statistical analysis, compare the age of onset, gender, immune index, syndrome distribution and kidney deficiency and cold syndrome and deficiency of kidney and blood stasis syndrome distribution of age differences.Results and Conclusion:1,Male AS patients were more than female patients, but in recent years the incidence of female patients were an upward trend, which can not be ignored. 2, Male AS patients with HLA-B27 had a higher positive rate than the female’s, female patients with HLA-B27 negative can not be ignored, we should pay attention to the misdiagnosis of female patients. 3, ESR, CRP detection has certain reference significance for diagnosis of AS in active stage. But when the detection of ESR, CRP negative also do not exclude the possibility of AS in active stage. 4, patients with AS syndrome type activity period distribution from high to low is kidney deficiency and cold syndrome, kidney deficiency and blood stasis, retention of damp heat, cold dampness syndrome and deficiency of liver and kidney. There are differences in gender distribution regularity of syndrome. Men with the overall syndrome distribution law. Women syndrome distribution from high to low is kidney deficiency and cold syndrome, kidney deficiency and blood stasis, cold dampness syndrome, retention of damp heat and deficiency of liver and kidney. 5, The age of onset of cold syndrome of active AS in male patients with renal deficiency and up to 20-40 years old; deficiency and blood stasis syndrome onset age up to 40-60 years old. From the male prevalence of age on the whole, the patients over 60 years old with a rising incidence, clinical on elderly patients should pay attention, to avoid missed diagnosis. 6, The active stage of AS in female patients with renal deficiency and cold syndrome age up to 20-40 years old; kidney deficiency and blood stasis syndrome in patients with age up to 40-60 years of age and older than 60 years. The age of onset in female patients with larger span AS, 20-60 year old renal deficiency and cold syndrome more visible, and more than 40 years old of kidney deficiency and blood stasis syndrome more common. Female patients with AS onset occult symptoms than men, relatively the male is light, easy to misdiagnosis and missed diagnosis, this may be the age of onset of AS in female patients with larger and wider distribution range of the age of reason, pending further study.