Effects Of Sancai Sanhuang Jiangtang Powder On Blood Glucose, Inflammation, Oxidative Stress And Endothelial Injury In Pre - Diabetes Mellitus (Qi - Yin Deficiency Type)

Objective:To observe the influence of SANCAI-ERHUANG POWDER on blood glucose, inflammatory factor, oxidative stress factors and vascular endothelium injury factors in pre-diabetes patients (Qi-Yin deficiency type)Methods:80 outpatients diagnosed with pre-diabetes (Qi-Yin deficiency type) were recruited in the study, randomly divided into the two groups:40 patients in control group (Group A) and 40 patients in trail group (Group B). The control group only received the lifestyle intervention, the trail group received both taken SANCAI-ERHUANG POWDER and lifestyle intervention. After 12 weeks of treatment, we observed and compared the change of fasting plasma glucose (FPG), 2-hour postprandial plasma glucose (2hPG), glycosylated hemoglobin (HbA1c), Inflammatory factor, high sensitivity C-reactive protein (Hs-CRP), tumor necrosis factor-α (TNF-α), interleukin-6, oxidative stress factor, malondialdehyde (MDA), superoxide dismutase (SOD), oxidized low-density lipoprotein (Ox-LDL), vascular endothelium injury factors, von willebrand factor (vWF), vascular endothelial-1 (ET-1) between before and after treatment.Results:1) FPG,2hPG, HbA1c decreased significantly after treatment in trail group (p<0.05),2) HsCRP、SOD、ET-1 decreased after treatment in both groups, the difference was statistically significant (p<0.05 in control group), (p<0.01 in trail group), there are more significantly decreased in the trail group, there are statistically significant differences between both groups after treatment(p<0.05); 3) The difference of IL-6,MDA,vWF between before and after treatment in trail group was statistically significant (p<0.05). The difference was not statistically significant (P> 0.05) between the two groups after treatment. The difference was not statistically significant in control group (P> 0.05); 4) The difference of TNF-α、Ox-LDL between before and after treatment in both groups and after treatment between both groups was not statistically significant (P>0.05); 5) In the experiment process, security index showed no significant abnormality.Conclusion:SANCAI-ERHUANG POWDER, in a certain degree, can lower blood sugar and glycosylated hemoglobin, reduce inflammatory factor and oxidative stress reaction, increase the body’s antioxidant capacity, protecting vascular endothelium and reduce various complications caused by hyperglycemia in pre-diabetes patients (Qi-Yin deficiency type). Prevention or delay the development from pre-diabetes to diabetes mellitus is expected.