Study On Tissue Screening And Liver - Protecting Effect Of Total Flavonoids And Oyster Protein In

The effect is of Total Flavonoids of Hippophae Rhamnoides and protein of oyster in acute hepatic injury mice induced by CCl₄ and alcohol was studied in this paper,The effect is of therapeutic hepatitis is clear.So,wo study the compound of Total Flavonoids of Hippophae Rhamnoides protein of oyster（1:1,1:2,2:1）,the result of compound （1:1）is the best for protecting effects on mice.The optimization compound is studied in injury mice by CCl₄、alcohol、APAP.We study its work mechanism innitally.From the results,Total Flavonoids of Hippophae Rhamnoides and protein of oyster both could decreased the ALT、AST activities in acute hepatic injury mice induced by CCl₄,also could decreased the TG、MDA concentration in acute hepatic injury mice induced by alcohol.At the dosage,the effect the compound（1:1）is the best.The compound（1:1）has no significant effect on body weight of mice,but it could decreased the ALT、AST activities in acute hepatic injury mice induced by CCl₄ and APAP,it also could decreased the TG、MDA、GSH concentration in acute hepatic injury mice induced by alcohol.They all displayed the effects in dosage-dependent manner. Otherwise,we studied the mechanism of the compound working.The compound could increase the ADH activity in hepatic tissues of mice induced by alcohol.