Comparison On The Effect Of Myelography With Iohexol And Iopamidol

Myelography is that which is injected with contrast mediums through cisterna magna to arachnoid subdurale at the site of foramen occipitale magnum. It can be used to assess spinal cord and diagnose spinal cord compression injury,mediastinal phyma diseases of spinal canal,vertebrae and spinal canal variation, and arachnoid adhesion. Iohexolin and Iopamidol are excellent second-generation nonionic hydrosoluble contrast medium, which made myelography clearly. This study purposes to provide basically science theoretic and technique to diagnose canine spondyle diseases. Myelography with Iohexol and Iopamidol were performed in 5 canines by puncturing cisterna magna from foramen occipitale magnum. With observing the radiograph quality and prolonged image of Iohexol and Iopamidol, their doses and myelography effects to canine vertebrate were compared, and the optimum dose of both contrast mediums was chosen. The results showed that the myelography effect is relative to contrast medium doses. 0.30mL/kg Iopamidol had the same myelography effect as 0.45mL/kg Iohexol. Both the two contrast mediums were cleared up in vertebrate at 10h after myelography. Iohexol had lightly image in thoracic and lumbar vertebrate myelography at 8h, but Iopamidol had unclear image in lumbar myelography at 8h. The results demonstrated that, myelography could be effective, simple and safe, which was performed with contrast mediums injected through cisterna magna to arachnoid subdurale at the site of foramen occipitale magnum. The effect of Iopamidol myelography was better than Iohexol myelography at same dose, and Iopamidol was vent quicker than Iohexol in vertebrate tube.