Formation Reason And Nourishment Adjustment Of Dog Kidney Xanthine Concretion

Dog xanthine calculus is a peculiar disease, it is caused by the deficiency of innatexanthine oxidase, it has not been reported that is caused by other postnatal factor. Thisstudy indicates the fluorosis can bring out xanthine calculus in dog kidney. The mechanismof xanthine calculus forming is that a mass of fluorine restrain the function of xanthineoxidase, resultingly, hypoxanthine and xanthine can not be converted into uric acid, thenhypoxanthine and xanthine is saturated and finally leading to xanthine calculus.According to the investigation of the disease's prevalence in the dog herd, the analysisof the clinical case and pathological change, the observation of the dog kidney functionparameters and kidney dissection, and the other exports' opinions, it can be proved that theoutbreak and death of kidney disease is caused by xanthine calculus and renal failure.For finding out the formation reason of xanthine concretion, according to the relativeanalysis between the dog age, breed, breeding field, exercise time in high-temperaturecircumstances, feedstuff etc with renal function parameters, it is showed that theinappropriate feedstuff is the primary reason which brings out kidney xanthine calculus.For checking out the harmful composition in the animal feedstuff, fluorine, lecithin, yeastpowder, chicken powder, soybean flour, fishmeal, wheat middling has been regard as thesuspected factors on further study. It is proved in guinea pig feeding trial that fluorine is theprincipal factor of impairing kidney function and life-span. It is indicated in dog feedingtrial yeast powder and fluorine are the main factors of the xanthine calculus forming.According to the study of the poison effect of fluorine and yeast powder, it has beenfound that it can do harm to kidney function and induce the increasing of renal functionparameters by high doses of fluorine and yeast powder. Due to the coexistence of the twomatters, they can severely impair the kidney function and leading to the xanthine calculusin kidney, and even the death, although uptaking the safe dosage of purine (6.13 mg/kg/d)and fluorine (7.81 mg/kg/d).In order to alleviate the harm and clinical symptom of fluorosis, first must handle thexanthine calculus mainly depend on nourishment adjustment to thedog herd, also need toconsider the bane of the fluorine simultaneously, because the dog kidney xanthine concretion is been poisoned by the fluorine. We have changed feedstuff, such as feeding thefood with low fluorine(＜18mg/kg), increasing the concentration of bivalent metal calcium,iron, copper, zinc, magnesium, aluminium and enhancing cellulose level etc., to counteractthe poisonous effect of fluorine, alleviate the harm, and accelerate the excretion of fluorine.Reducing the concentration of purine and protein and basifying urine can do good to thekidney function, reduce the intake of purine from food, and reduce the forming of xanthinecalculus. Adding vitamin c, vitamin e and lycopene can alleviate the harm of free radicalcaused by fluorosis. After been adjusted by the nourishment, all the clinical symptoms ofthe dogs have been mitigated, all of the serum urea nitrogen parameter have declined,declining to normal scope mostly, contrary all the dogs that have not adopted nourishmentadjustment died, dissect the bodies discover that the kidney contain a great quantitiesxanthine concretion.