The Relationship Of Vitamin E And Helicobacter Pylori To Gastroduodenal Diseases

Objectives: to investigate the relationship between vitamin E (yE) concentration in serum and Helicobacter pylori(Hp) infection to Chronic gastroduodenal diseases. Method: we have Used Reverse phase High pressure liquid Chromatography to investigate vitamin E level in serum of 162 patients whose endoscopic and pathobiologic diagnoses were normal(n=12),chronic gartritis(GC n=66),gastric ulcer(Gu n=26),duodenal ulcer(Du n=33),gartric carcinoma(Gca n=25).At the same time,Helicobacter pylon were also examined. Results: The results showed that 84 of the 162 patients was infected by Hp(51,85%) ,78 of the 162 patients was not infected by Hp(48.15%).The serum level of vifamin E wasn抰 significantly Compared in Hp positive patients with negative patients(P>0.05). The vitamin E level was significantly lower in CG(8.5280?.7222 Il glrnl),Gu(8.1788?.8117 ~L g/ml),Du(8.2630 ?1.9182 i~i g/ml),Gca(8.3064 ?3.0585 Ii gIml), than in normal mucosa(13.1433 ?1.3929 ii g/ml) (P<0.05). Hense has direct relationship with intestinal metaplasia and atypical hyperplasia.However there is not a close relationship between the serum level of VE and gastrointestinal diseases. Conclusion: This study indicates that there are not correlation exists between yE in serum and Helicobacter pylon. But has direct relationship with gastroduodenal diseases; this in turn suggests that the lower the level of VE the high the risk of gastroduodenal diseases is.