Title:Investigation Of The Relation Between Level Of Matrix Metalloprotease In Plasma Of Acute Coronary Syndrome

Background and objective: Matrix matalloproteases (MMPs),especially MMP-9, play an essential role in the disrupture of atherosclerosis plaque which may result in acute coronary syndrome including unstable angina .Acute myocardial infaction and sunden death.The MMP-9 can specially degrade basic membrane, which is necessary to pass through the basic membrane . Resently,the research for the expression of MMPs in body fluid is less.Therfore ,this study is to investigate level of MMP-9 in patients with ACS to learn whether we may provide a convenient and simple method for predicting the unstability of AS lesion. Method: To use the ELISA investigates the level of patients with 24 UA,24AMI,l7EAand l7control. Result:The level of MMP-9 is increased in patients with ACS compared with EA and control groups. Conclusion: Measuring MMP-9 may be a convenient and efficient method to predict the unstabiity of AS plaque.