Efficacy And Tolerability Of Irbesartan In Patients With Mild To Moderate Hypertension

Objectives. To compare the antihypertensive effect and safety of the angiotensin II receptor antagonists Jrbesatan and Valsartan The efficacy and tolerability of Lrbesartan was evaluatedMethods:fifty-three patients with mild-to- moderate hypertension were randomized to two groups in double-blind manner One group was treated with Jrbesartan 75-l5Omglday(group A), the other group with Valsartan 80-l6Omglday(group B), for 4 weeks Sitting blood pressure, heart rate and laboratory examination of the patients were observed at baseline and post-treatment Adverse reactions were recorded4Results: Diastolic blood pressure was reduced in the Irbesartan group by 13 3±8.7 nimHg and in Valsartan group by 165±93mniHg. Efficacy was achieved m 760% of patients in group A and 84.0% in group B (P>O.05). The blood pressure was controlled at starting dose in 72.0% for patients in group A and 68.0% in group B (P>0.05) Adverse reactions were infrequent in both groups.Conclusions: Irbesartan was effective, safe, reliable and welltolerated in the treatment of mild-to-moderate essential hypertension.