A Study Of The Expression In Hepatic Cancerous Tissue Of Senescence Marker Protein-30(SMP30),a Tumor Associated Antigen Of Hepatic Carcinoma,and Its Signficance

Objective:To investigate in hepatic cancerous tissue the expression of SMP30 and its specificity. Methods: The expression of SMP30 in hepatic cancerous tissue, paracancerous hepatic tissue, the tissues of benign liver diseases and the tissues of other extrahepatic carcinomas were tested by RT-PCR technique. Results: Of the 24 cases of primary hepatic carcinoma (PHC), SMP30 was detected in the hepatic cancerous tissue of 17 cases (70.83%) and in the corresponding paracancerous hepatic tissue of 10 cases (41.67%), SMP30 was also detected in 4 of the 13 cases of benign hepatic tissues (30.77%) and in 6 of the 26 cases of extrahepatic carcinomas (23.08%) respectively. The rate of expression of SMP30 in hepatic cancerous tissue was significantly higher than in the rest of the tissues (P <0.05 or P <0.01), but there was no clear difference in the rates of expression among the latter. The sensitivity and specificity of SMP30 in the diagnosis of PHC were 70.83% and 68.25% respectively. Conclusion: SMP30 is an associated antigen of PHC, with a considerable specificity in its expression in hepatic cancerous tissue, and could play a significant role in the diagnosis of PHC.