| The pathogenesis of the psoriasis has not been made completely clear. It is to be thought at present that psoriasis is a kind of immunization abnormality disease based on heredity and mediated by T lymphocytic cell. Meanwhile, the psychosomatic disorders attributes of psoriasis has gain widespread attention. The main psychosocial factors of causing psoriasis may through Hypothalamus, hypophysis, cerebral cortex to influence endocrine hormone and autonomicnerve release, the patient's immune system is also affected . Biofeedback (BF) is a kind of effective behavior therapy, with this method we has got good curative effect in treating 31 Psoriasis patients in 1993( 86%). In 1990, Yang XueQin with other researchers adopt the normalized Heart Rate Variability in determination of psoriasis patient's autonomic nerve functional status both before and after biofeedback therapy. They found that patient's sympathetic nerve excitability and parasysmpathetic tension had been improved obviously after biofeedback treatment. In order to try to find out reason of biofeedback therapy of treating psoriasis, in this paper, we carry out our experiments, research and summarization from both respects of endocrine and immune.We determined the level of 30 Psoriasis patient's blood plasma angiotensin II with the I'23 equalized competition radiation immunization analysis (RIA), and compared the results with that of 24 control group. It has been found that the levels of blood plasma angiotensin II in psoriatic patients were within the normal range of kit, but they were much lower than that of the normal controls in this study. The level of blood plasma angiotensin II of psoriatic patients was 38.7pg/mL, and the mean value of the normal contrast group is 86.99pg/ml, there are significantly difference. In addition, we had determined the angiotensin II level of 10 psoiiasis patients out of the 30, who had insist on biofeedback therapy more than 3 months, and got the result that their angiotensin II level was 62.24pg/ml, which was significantly improved than that of 35.75pg/ml in pretreatment. The difference was significant.Meanwhile, we adopted the S.P method on 30 Psoriasis patients and 20 normal contrast group members to detect their peripheral blood CD3 CD4 and CD8T cell percentage. We found that in progress period psoriasis patient's CD3Tcell was lower than that of contrast group , but there was no significant difference(P>0.05).While CD4 T cell percentage was significantly lower than that of normal contrast group(P<0.01), and CD8T cell percentage was higher significantly than that in normal group people (P<0.01), the difference was extremely significant. After the biofeedback therapy, the patients' CD3T cell mean value was 66%, it was close to normal value, and was raised higher than that in pretreatment (58%)(P<0.05), the difference are significant , CD4 T cell mean value was 35.6% that was in normal low range and was higher than pretreatment (27.6%)(P<0.01), the difference are extremely significant, But the CD8T cell percentage descended not significantly (P>0.05).It is made clear from above research result that the low level of angiotensin II in psoriasis patients is to hint that angiotensin II regulating function may be unbalance and it may take some role in the process of provocation of psoriasis. The abnormal of CD3, CD4 and CDg T cell percentage confirm that there are unbalance of endocrine and immune in psoriasis patient body. After biofeedback therapy, patients condition got well and some of them had been fully recovered, their blood plasma angiotensin II level and their peripheral blood CD3, CD4 and CD8 percentage had been improved in different extents. The result showed that biofeedback therapy may not only adjust autonomic nerve functions in , but also take part in adjusting endocrine and immune functions. The research carried out in this paper provided certain theoretical support to the biofeedback therapy in treating psoriasis, and it helpful for both doctor and patient to deepen their knowledg...
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