| Background SM has special advantages in cardiovascular diseases treatment as Chinese conventional herb medicine, many animal experiment and some clinical study indicate that SM injection has acted on many periods in coronary heart disease, break off pathology progress, improve left ventricular diastolic function, the mechanism is mainly antioxidation, but there are few studies in human?s correlating the therapy effect with increased free radical injury and antioxidation, few studies in influence of left ventricular function, and even no studies in coronary heat diseases patients correlating oxidation and antioxidation with ultrosonic- cardiographic left function evaluations. Objectives We sough to study antioxidatant effect and influence on left ventricular function of patients with stable angina treated by SM injection. Methods Eighty patients were randomized to received either basic therapy or suppiemented with SM for 10 days. In addition to clinical evaluations, we measured markers of oxidative (MDA) and defense against oxidative stress (SOD,GSH-Px) and left diastolic and systolic function by UCG. Results The patients age, genda, drug intake, coexist disease are comparable in basic treatment groups and SM groups: 1.There was a significant difference of MDA, SOD, GSH-Px, SOD/MDA, ~\ MDA, A SOD, A GSH-Px, SM group has more improvement. P<0.05 or P<0.01. 5 2.There was a significant correlation between improvement of clinical syndrome, ECG (electric-cardiography) and those oxidant and antioxidant variable ,P |
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