A Study On Pharmacokinetics And Acute Toxicity Of 1,6 Fructose Diphosphate Magnesium Preparation

This was a study on comparison of pharmacokinetics of fructose 1,6 diphosphate magnesium (FDP-Mg) preparation and magnesium sulphate (MgSO4) indirectly through determination of total plasma magnesium before and after intravenous administration by using atomic absorption method. Dixon-Mood sequential method was employed to determine LD50 and LD1 of FDP-Mg for preliminary evaluation of its acute toxicity and maximal tolerance dose when given by constant intravenous administration. Experimental results showed that both FDP-Mg and MgSO4 followed two-compartment model. The volume of the central compartment (Vc) of FDP-Mg was significantly greater than MgSQ4(P0.048). Compared with MgSO4, FDP-Mg remained longer in the central compartment and its total elimination was faster as well. The sequential method generated LD50 of 5.464 (95% confidence interval: 4.902 6.026) mg/ ( kg mm ) and maximal tolerance dose ( LD1 ) of 3.757 mg/kg/mm respectively for intravenous administration of FDP-Mg at a constant rate. This study proved that magnesium of FDP-Mg distributed to central compartment more readily than that of MgSO4, giving a pharmacokinetic basis for the special therapeutic efficacy of FDP-Mg. Furthermore, FDP-Mg was less likely to accumulate in the body and was therefore considered to be safer. Conclusively, intravenous FDP-Mg at a constant rate is a more suitable route of administration for clinical treatment.