Hepatitis B Virus Basal Core Promoter Mutations In Patients With Chronic Hepatitis

ANSTnsCTObjective To investigate the mutant significance of HBVBCP in patents with chronic hepatihs B virus infection.Methods Combining polymerase Chain reaction withELISA, mutants (nt1762A -T and 1764G-A) of HBVBCP in 74 patients with chronic hepatitis B virus infectionwere studied. ResultS The T1762 and A1764 mutants inHBV BCP region was founded in 24 (24/74) patients withchronic HBV infeCtion.The rate of HBV BCP mutants innegative and POsitive groups of HBeAg was 42.9%(18/34)and 18.7% (6/32) respectively to<0.05). The quantity ofHBVDNA in mutant group (10'.,""'.ase,copy/ml) wassignificantly higher than that in non-mutant group(10'.""".""coPy/ml) (P<0.001). The POsitive rates ofmutants in chronic fulminant hepatitis B and innon-fulminant groups were 63.6% (7/11) and 27% (l7/63)respectively to<0.05). ConcIusion The T1762A1764 mutantsin HBV BCP regioll cotild lead to the negative of HBeAg3and the replication of HBVDNA .The mutation in BCP region might be correlated to the occurrence of fulminant hepatitis.