Effects Of Acute Normovolemic Hemodilution On Cardiac Troponi I And Myocardial Enzyme

TO investigate the effects of acute normovolemic hemodilution on cardiac troponin I(CTnI) and myocardial enzyme.Methods Twenty-nine patients,ASA grade Ⅰto Ⅱ,having lebectomy of liver or bilateral hip replacement with general anesthesia were acted as subjects.They were divided at random into hemodilution group(H group,n=15) and control group(C group,n=14).Serum CTnI,CK and CKMB concentrations were measured before induction of anesthesia,prior to retransfusion of blood components,4h after surgery,and on the first postoperative day.Results: ⑴Porior to retransfusion of blood components,the hematocrit was decreased to 20.33±1.91%(mean±SEM) in H group and to 29.64±1.78%(mean±SEM) in C group.At the same time,there was a significant difference in the hematocrit between both groups(P<0.01). ⑵CK,CKMB mass increased significantly in each groups,while they did not differ satistically between the groups. ⑶In contrast,CTnI remained below the upper reference limit(≤2.3ng·ml) at any time.No statistical difference was found in and between both groups.Cinclusions: We suggest that pre- and intraoperative hemodilution to a hematocrit of approximately 20% by maintaining normovolemia and administering 100% oxygen does not result in myocardial fiber injury in patients without preexisting cardiaopulmonary dieases.