The Telomerase Activity Of Maternal Blood And Fetal Cord Blood In Pregnancy Induced Hypertension

Objective Telomerase was a mark of cellular proliferation activity in molecular level. This study investigates the telomerase activity of peripheral blood mononuclear cells from patients with Pregnancy Induced Hypertension (PIH). Methods Venous blood were collected from 30 non-pregnant heathy women ^ 33 normotensive pregnant women in third trimester and 35 patients with PIH. Umbilical venous blood were collected from 33 newborns in normotensive pregnant group and PIH group, respectively. The telomerase activity of peripheral and umbilical blood mononuclear cells was evaluatedby telomerase-PCR-ELISA assay. Results (1)The telomerase activity of maternal peripheral blood mononuclear cells in PIH group was significantly greater than that in normotensive pregnant group and non-pregnant heathy group, while no difference was found between two control groups; (2)The telomerase activity of umbilical blood mononuclear cells in PIH was significantly greater than that in normotensive pregnant group; (3) The telomerase activity was positively correlated with the severity of the disease; (4) There was no difference in telomerase activity before treatment and after treatment 5-8days. Conclusion Patients with PIH had higher telomerase activity. The result suggested that elevated telomerase activity in patients with PIH might take part in the pathogenesis of PIH.