Clinical Study On Nitric Oxide, Endothelin And Calcitonin Gene-Related Peptide Of Lung Cancer Patients

Objective Study the significance of nitric oxide (NO), endothelin (ET-1) and cal-citonin gene-related peptide (CGRP) in the early diagnosis, substaging, subtyping, prognosis and patient's condition judgement of lung cancer; further clarify whether or not NO, ET-1 and CGRP can he regarded as a monitoring index in the malignant growth of lung cancer or, at the same time, as an index in the judgement of differentiation extent and treatment outcome of lung cancer.Method detecting the NO, ET-1 and CGRP levels in plasma in the lung cancer patients group, pulmonary heart disease patients group and control group by employing radioactive immunizing method and chemical colorimetry.Result The NO, ET-1 and CGRP levels in the blood plasma of lung cancer patients are substantially higher than those of the corpulmonale patients group and control group. The difference is significant. With the development of patients' condition, the levels further increased. The difference takes on statistical significance. The ET-1 level is the highest in patients at the HI + IV stages of NSCLC, while the CGRP level increases most obviously during the extensive period of SCLC. Among other things, the three above-mentioned indices of NSCLC patients at the + IV stages are obviously higher than at the I + U stages, while those of the SCLC patients in the extensive period obviously higher than in the localised period. The difference is significant. In the early stage of lung cancer, i. e. the I + D stages of NSCLC or the localised period of SCLC, the three indices of blood plasma have obviously increased to be significantly different from those of the control group, which prompts that the three indices will have increased obviously in the early stage of lung cancer and can be regarded as an index in the diagnosis of early lung cancer. What has also been discovered is that, as to the comparison of NSCLC with SCLC, the ET-1 level at the I + II stages of NSCLC is higher than in the localised period of SCLC, but the difference is not significant; the differencebecomes significant when in the HI + IV stages and extensive period respectively. The CGRP level in the localised period is higher than in the I + fl stages with a insignificant difference, however it becomes appreciably higher in the extensive period than in the HI + IV stages. The above discovery prompts that the difference in the increment of ET-1 or CGRP level will have a certain guiding significance in the judgment of the pathological typing of lung cancer patients. After surgical removal, the CGRP, ET-1 and NO levels in the blood plasma of lung cancer patients lowered substantially compared with those before the operation, the difference is significant. The concentration of CGRP, ET 1 and NO in blood plasma is correlated with the differentiation extent of lung cancer. Therefore, this study prompts that there is positive correlation between the two aspects. The CGRP and ET-1 levels in the blood plasma of the pulmonary heart disease patients group is appreciably higher than those of the control group and the difference is significant, while the NO obviously lower than that of the control group, which prompts that CGRP, ET-1 and NO of the blood plasma take part in the pathologic and physiological processes of pulmonary heart disease.Conclusion This paper prompts that the NO, ET-1 and CGRP levels are one of the indices in the early diagnosis of lung cancer, and also one of the indices in judgement of severity and clinical substaging of lung cancer. It also prompts that the different extent of increasing of ET-1 or CGRP has a certain guiding significance in the differentiation of NSCLCand SCLC. It further prompts that the CGRP, ET-1 and NO of blood plasma take part in the pathologic and physiological processes of the lung cancer patients.