Role Of Plasma Oxidized Low Lipoprotein In The Renal Diseases

Objective: To investigate the plasma levels and role of oxidized low density lipoprotein(ox-LDL) in patients with renal diseases, and to study effect of hemodialysis on the plasma oxidized low density lipoprotein levels.Methods: This study included 226 patients. Patients were divided into six groups. The first group is 54 nephrotic syndrome patients. The second group is 18 chronic nephritis patients. The third group is 92 chronic renal failure patients. The fourth is 13 diabetic nephropathy patients without renal failure. The fifth is 12 diabetic nephropathy patients with renal failure. The sixth is 37 hypertensive nephrosclerosis patients without renal failure. The seventh(control group) is 111 healthy subjects. Chronic renal failure patients were divided into three groups according to hemodialysis: The first group is 39 patients without hemodiahysis treatment; The second group is 33 patients with hemodialysis treatment for less 3 years; The third group is 20 patients with hemodialysis over 3 years. Chronic renal failure patients without hemodialysis treatment were divided into two groups according totheir serum creatinine (Scr): the group A had Scr<450 u mol/L and the group B had Scr>450 u mol/L. Chronic renal failure patients were divided into two groups according to complicated coronary heart disease: The first group is 47 chronic renal failure patients with coronary heart disease; The second group is 45 chronic renal failure patients without coronary heart disease. The blood samples of all subjects were collected after fasting for 12 hours. The blood samples were collected before and after hemodialysis in 53 patients with chronic renal failure. The plasma ox-LDL levels were measured with ELISA. Serum TC TG HDL-C LDL-C. Scr and ALB levels were measured with automatic biochemistry analyzer.Results: 1. The plasma levels of ox-LDL were significantly elevated in patients suffering from nephrotic syndrome, chronic renal failure, hypertensive nephrosclerosis compared with control subjects (p<0.05). The plasma levels of ox-LDL were no differences between the patients suffering from chronic nephritis, diabetic nephropathy without and with renal failure and control subjects(P>0.05). The plasma levels of ox-LDL were significantly elevated in patients suffering from chronic renal failure compared with patients with nephrotic syndrome and diabetic nephropathy without renal failure(p<0.05). 2. Among chronic renal failure patients without hemodilialysis, the plasma levels of ox-LDL in group A didn'tdiffer from those in group B (P>0.05). 3. The plasma levels of ox-LDL in patients suffering from chronic renal failure without hemodialysis were significantly lower than those in patients suffering from chronic renal failure with hemodialysis for less and over 3 years (P<0.05). The plasma levels of ox-LDL were no differences between patients suffering from chronic renal failure with hemodialysis for less and over 3 years (P>0.05). The plasma levels of ox-LDL in patients with chronic renal failure after hemodialysis were not significantly lower than those in patients with chronic renal failure before hemodialysis (P>0.05). The plasma levels of ox-LDL in patients with chronic renal failure with coronary heart disease were significantly higher than chronic renal failure without coronary heart disease.Conclusions: (1)The levels of plasma ox-LDL were elevated in patients with chronic renal diseases. The levels of plasma ox-LDL were higher in patients with end-stage renal disease with coronary heart disease than the other renal diseases. The levels of plasma ox-LDL may correlate with development of renal lesion and may be an important risk factor for complicated coronary heart disease.(2)Hemodialysis can't reduce the plasma levels of ox-LDL.(3)The levels of plasma ox-LDL in patients with diabetic nephropathy were not significantly elevated. It may correlate with higherlevels of plasma glycated LDL in patients with diabetic nephropathy.