Chronic Renal Failure Syndrome Distribution Law Research

Background:In the past half-century, despite renal replacement therapy in chronic renal failure has made great progress, saving the lives of large numbers of patients, as most fields of kidney disease breakthrough flash point. But global number of chronic renal failure undergo dialysis increase to 1,065,000 during last 10years,ankd in 2010 the number will reach to 200 million people. The increase in the number, resulting the rapid growth in medical expenses for dialysis. Few countries in the world can afford such a medical and financial needs. This gives the community a great burden. Therefore, there is a considerable significance of society to prevent and cure CRF actively and to delay its developing. Traditional Chinese medicine (TCM)plays more and more important role on the early and mid-CRF prevention, for it has been proved to have effect of relieving symptoms and delaying its developments before the stage of uremia.Objective:To investigate the distribute regulation of TCM symptom-sign in chronic renal failure patients. Then apply reference frame for clinical and basal study of CRF.Methods:On the foundation which checks related articles and books extensively, combines the authoritative CRF syndrome differentiation certificate of present stage, and ask for experts'opinion, design "the investigate form for CRF symptom-sign of TCM". We use of the cross-sectional study of methods for the collection of traditional Chinese medicine syndromes in patients. We collected 370 cases of patients with CRF from Xiyuan Hospital. Ask for the help of covariance software of the spss 13.0, use frequency to analysis the distribution of each kind of symptom.Results:1 The frequency analysis shows that in these 370 cases, deficiency of both QI and YIN of the spleen and kidney is the majority type, the secondly is deficiency of YANG of the spleen and kidney and have a increase trend gradually with the renal function decease, the thirdly is deficiency of QI of the spleen and kidney.The damp-heat symptom has the highest occurrence, the secondly is blood stasis, the least is wind-pathogen symptom. The damp-heat symptom has the reduce trend from compensatory phase to uremia, and the blood stasis and damp-muddy symptom have the increase trend from compensatory phase to uremia.2 The relationship between the deficiency symptom and the empirical symptom:Kinds of he empirical symptom has the different distribution in kinds of the deficiency symptom. The blood stasis has the highest occurrence in deficiency of both YIN and YANG, and the damp-heat symptom has the highest occurrence in the deficiency of both QI and YIN of the spleen and kidney. The water-pathogen symptom is mainly appeared in deficiency of QI of the spleen and kidney and deficiency of YANG of the spleen and kidney, and the wind-pathogen symptom is mainly appeared in the deficiency of QI of the spleen and kidney and deficiency of both YIN and YANG.3 The primary diseases of CRF are Chronic nephritis, Chronic pyelonephritis, Diabetes and Renal vascular disease. This investigation shows that there is no difference in the distribution of symptom-sign between the primary diseases.4 The deficiency of both QI and YIN of the spleen and kidney and the damp-heat symptom have the highest occurrence in the CRF patients which do not have dialysis yet. The deficiency of QI of the spleen and kidney and the damp-heat symptom have the highest occurrence in the hemodialysis patients. The deficiency of YANG of the spleen and kidney and the damp-muddy symptom have the highest occurrence in the peritoneum dialysis patients.Conclusions:In the study above, we had designed a questionnaire to investigate the features and distribution of TCM Symptoms of CRF with clinical epidemiological method. We have analyzed the collected data with modern statistical method, such as frequency distribute, rate.1 The deficiency of YANG of the spleen and kidney and the deficiency of both QI and YIN of the spleen and kidney have the highest occurrence in the deficiency symptom. The damp-heat and the blood stasis symptom have the highest occurrence in the empirical symptom.2 The relationship between the deficiency symptom and the empirical symptom:Kinds of he empirical symptom has the different distribution in kinds of the deficiency symptom. The blood stasis has the highest occurrence in deficiency of both YIN and YANG, and the damp-heat symptom has the highest occurrence in the deficiency of both QI and YIN of the spleen and kidney. The water-pathogen symptom is mainly appeared in deficiency of QI of the spleen and kidney and deficiency of YANG of the spleen and kidney, and the wind-pathogen symptom is mainly appeared in the deficiency of QI of the spleen and kidney and deficiency of both YIN and YANG.3 This study shows that there is no difference in distribution between the primary diseases.4 This study shows that there is difference in distribution between the CRF patients which do not have dialysis yet and the dialysis patients.It also shows that there is difference in TCM symptom between the hemodialysis patients and the peritoneum dialysis patients.