| Objective: In order to investigate the genetic factor and pesticide exposure on primary dysmenorrhea in twins in rural area. Methods: We carried out a large scale cross-sectional study in Anhui Province. According to the standard questionaire, informations on primary dysmenorrhea and pesticide exposure, sociodemographic and related environmental and occupational variables were obtained by trained interviewers. To identify zygosity of twins, ten highly polymrophic genetic markers were selected and scanned on ABI377 machine. All the data were double entried and checked by EPI INFO and analyzed by SAS. Results: In the Study One, we totally collected eligible 1311 pairs of twins, 908 Monozygotic twins(MZ) and 403 Dizygotic twins(DZ). Logistic regression was applied to analyze the risk of the same degree primary dysmenorrhea in twins with and without adjustment for confounding factors. The results showed that OR value was significant in MZ and OR value was also significant except for severe primary dysmenorrhea in DZ. In additon, OR value of MZ was higher than that of DZ. In the Study Two, we collected 3286 eligible female. Logistic regression was applied to analyze pesticide exposure on primary dysmenorrhea with and without adjustment for confounding factors. The result revealed that pesticide(P<0.01) ()R=1.235 ( 95%CI: 1.054-1.446) was singnificantly associated with primary dysmenorrhea. Meanwhile, age and stress were also singnificantly associated with primary dysmenorrhea. Conclusion: In Study One, the results demonstrated that primary dysmenorrhea was heritable. The effects of genetic factors were different when the degrees of primary dysmenorrhea were different. In study Two, pesticide exposure was singnificantly associated with primary dysmenorrhea in twins, the incidence ofprimary dysmenorrhea increased with pesticide exposure. The results demonstrated that pesticide exposure was the risk factor of primary dysmenorrhea in twins.
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