The Expression And Their Clinical Significanceof DPC₄/Smad₄ And Nm23-H₁/NDPK In Pancreatic Carcinoma

ObjectiveTo explore the expression and correlation between DPC4/Smad4and nm23-Hl/NDPK in pancreatic carcinomaMethodsDPC 4./Smad 4. and nm23-Hl/NDPK were detected in tissuesamples from 34 cases of pancreatic carcinoma and 34 cases of chronic pancreatitis using SABC immuno-histological methods. Tissue samples positive to DDC4/smad4 and nm23-Hl/NDDK protein were analysed statistically by SPSSResultsDPC 4./Smad 4. was found to be significantly higher in chronicpancreatitis tissue than that in pancreatic carcinoma (p<0:05). nm23- HI/ NDPK was found to be significantly higher in pancreatic carcinoma than that in the control samples (p<0.05). nm23-Hl/NDPK positive results were found in cases with highly differentiated carcinoma, non- lymph node metastasis and clinical stage I--II were remarkably lower than that in the lower differentiated lymph node metastasis and clinical stage III?IV (p<0.05).No relation was found between DPC 4./Smad 4. and nm23-Hl/ NDPK, and neither were found to have any correlation with sex, age, size of tumor, clinical stage or pathological type.Conclusion:1. The results suggest that the presence of nm23-Hl/NDPK could serve as a marker for malignant potentiality and poor prognosis for pancreatic cancer.nm23-Hl/NDPK may not display the suppressive function in pancreatic carcinoma with lymph node metastasis.2. DPC 4./Smad 4. may be a tumor suppressive gene. Its alterations may play an important part during tumorigenesis and development of pancreatic cancer.