Study On Effect Of Hepatitis B Immunoglobulin In The Preventing Maternofetal HBV Transmission

Objective: To explore the preventive effect of mathernofatal Hepatitis B virus(HBV) transmission after pregnant women earring HBsAg and their newborns have been passive immunized Hepatitis B immunoglobulin (HBIG), and to study the factors influencing HBV mtrauterine transmission and clinical predicable indexes, and to discuss the breast-feeding problem of pregnant women earring HBsAg.Methods: 134 pregnant women caning HBsAg were choosen and divided into two groups: Groups A (n=66), which HBIG 200 IU was given monthly in late pregnancy; Group B (n=68), which abtained only common antenatal care. In addition, Pregnant women showing neither Hepatitis B virus immunological markers nor HBV-DNA were choosen as control group(group C, n=17). The newborns were also divided into three Groups: Group I and Group II abtained both HBIG and HBVac, and Group III abtained HBVac only. All the pregnant women and their newborns underwent an examination of HBV immunological markers and HBV-DNA at regular intervals.Results: 1 The positive rate of HBsAg of newborns (age=24h) in Group A was significantly lower than that in Group B.2 The newborn's birth weigh, height, one-minute Apgar scores, neonatal jaundice, congenital malformation, sex and other combinations had no significant difference among Group I , Group II and Group III.3 The incidence of postpartum hemorrhage, incisional infection, intrauterine infection had no significant difference among three groups.4 The HBsAg positive rate in colostrums of Group A and that of Group B had no significant difference. The HBsAg positive rate in colostrums of subjects in Group A and B correlated positively to the HBeAg positive rate of materal blood, respectively.5 As the infants were 6 months old, the positive rate of HBsAb was similar between Group I and Group II, The HBsAb positive rate of infants was signicantly higher in Group I than in Group III, there was not significant difference between Group II and Group III.6 As the infants were 6 months old, the HBeAb positive rate infant blood had no significant difference between breast-feeding and artificial-feeding.Conclusions: The pregnant women earring HBsAg should be given HBIG monthly during late pregnancy, offsprings should abtained HBIG and recombiant HBVac, these procedures can effectively reduce the positive rate of HBsAg of newborns.