The Effects Of Perioperative Allogeneic Blood Transfusion In Immune Function Of The Patients With Hepatocellular Carcinoma

Objective: The aim of this study was to investigate the changes in the levels of serum immunosuppressive acidic protein (IAP), soluble interleukin-2 receptor (sIL-2R), interleukin-6 (IL-6) and the counts of T-lymphocyte subsets in patients undergoing resection of hepatocellular carcinoma (HCC), trying to find the effects of immune function in the patients undergoing perioperative allogeneic blood transfusion.Methods: 46 patients undergoing resection of HCC, were randomly allocated to the group of non-receiving allogeneic blood transfusion (â… group having 19 patients) and the group of receiving allogeneic blood transfusion (â…¡group having 27 patients) during perioperative period. Alkaline phosphatase anti-alkaline phosphatase (APAAP) technique, double antibody sandwich ELISA were used to determine the counts of T-lymphocyte subsets and to detect the levels of serum sIL-2R and IL-6 on preoperative day 1 and postoperative day 4. The single radial immunodiffusion method was used to detect the serum IAP on preoperative day 1 and postoperative days 1,4,7.Results: The counts of CD3, CD4 in both groups decreased significantly after operation (P<0.05). The levels of serum IAP, sIL-2R and IL-6 in both groups elevated greatly after operation (P<0.01 or P<0.05). The increase of IAP was more obvious in â…¡group than in â… group(P<0.05).Conclusion: The operative strike contributes to the confusion of immune function in patients undergoing resection of hepatocellular carcinoma, and perioperative allogeneic blood transfusion makes it have more suppressive condition.