| Objectives The aim of the present study was to determine the role of AChRab in MG CNS dysfunction and to try to investigate the mechanism. Methods Rats were distributed to two groups, the model and the control. 40ul of IgG (AChRab) purified from the serum of 5 MG patients was injected to the rat lateral ventricular system once other day, 4 together, and the similar injections were operated on the control rats with the IgG purified form the serum of 5 healthy volunteers. The effects of AChRab on the CNS function were investigated with the electroencephalography (EEG) examination and the brainstem auditory evoked potential (BAEP) one day before and two weeksafter the injections, and by observing the rat's manifestations. The brain samples were acquired just after the examinations and hematoxylin-eosin (HE) staining and TUNEL staining were used to identify the cellular apoptosis taken place in them. Results In contrast with the control group, the model rats manifested some symptoms indicating not only the neuromuscular disorder but the CNS dysfunction. The EEG revealed the dysfunction of CNS which was characterized by the increment of 6 and 9 waves and single spikes or spike and wave complexes. And the BAEP examination also revealed the rats auditory pathway dysfunction characterized by I-III, III梀, I 梀 IPLs prolongation. Besides, neuron apoptosis increment was observed in some regions of the rat' s brains. Conclusion The CNS dysfunction in the models was ascribed to the AChRab introduced to the lateral ventricular system. Which was known to be a series of manifestations?anorexia, loss of weight, dull to response and reduced action, abnormal EEC which was characterized by the increment of 8 and 9 waves and single spikes or spike and wave complexes, abnormal BAEP characterized by I-III, III?V, I ?V IPLs prolongation, and increment of neuronal apoptosis in the brains.
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