Expression And Clinical Significance Of The E2F Family In Human Gastric Carcinomas

Objective:To study the expression and clinical significance of E2F-1 and E2F-3 in human primary gastric carcinomas and the relationship between expression of E2F-1 and E2F-3.Methods:Immunohistochemistry was used to detect the expression of E2F-1 and E2F-3 in the cancer tissues and their corresponding normal mucosa of 55 cases of human primary gastric carcinomas. Statistics was used to analyze the data.Results:The postive expression rate of E2F-1 in cancer tissues was 80%(44/55),while the postive expression rate of E2F-1 in corresponding normal mucosa was 29.09%(16/55); E2F-3 was present in 14.55(8/55) cancer tissues and 74.55%(41/55)corresponding normal mucosa. The positive expression rate was distinct difference between cancer tissues and normal mucosa about E2F-1and E2F-3(P<0.01). But there was no correlation between the positive expression of E2F-1 and E2F-3(P>0.05). The expression of E2F-1and E2F-3 in cancer tissues was not correlated with the tumor stage,pathological type,lymph node metastasis and the depth of invasion.Conclusion:The results suggest that E2F-1 is over expressed in gastric carcinomas, however E2F-3 is low expressed in it. And anomalous expression of the E2F gene may permit the gastric tumorigenesis and progression. The members of E2F family take different role in oncogenesis of stomach...