The Expression Of SNCG In Gastric Carcinoma And Its Relationship With MMP-2 And MMP-9

Objective: To study the expression and significance of SNCG in gastric cancer, and to explore the relevance of SNCG, MMP-2, and MMP-9 to gastric carcinoma.Methods: The observation of 60 gastric cancer cases, based on immuno-histochemical method, and the expression of SNCG protein, MMP-2 MMP-9 in 20 paraffin wax samples of normal gastric mucosa.Results: 1) The positive rate of SNCG protein in gastric carcinoma amounts to 65%, higher than the neighboring normal tissue(P<0.05); 2) the expression of SNCG is relevant to the depth of tumor infiltration, lymphatic metastasis, as well as the clinical staging of tumor(P<0.05); 3) the expression rate of MMP-2 arrives at 75%, and MMP-9, 68.3% respectively in gastric cancer, which is remarkably higher than the neighboring normal tissue(P<0.05);4)the expression of MMP-2 and MMP-9 are correlated with depth of gastric cancer infiltration, lymphatic metastasis, as well as the clinical staging of tumor(P<0.05); 5) and the correlations between the expression of SNCG, and that of MMP-2, MMP-9 are positive, which is the same to the relation between the expression of MMP-2 and that of MMP-9(P<0.05).Conclusions: The high expression of SNCG, MMP-2, and MMP-9 are closely associated with infiltration and metastasis of gastric cancer; the abnormal expression of SNCG, MMP-2 and MMP-9 are likely to jointly participate in the process of genesis and evolution of gastric carcinoma, therefore the detection of SNCG, MMP-2 and MMP-9, which reflect the pathological characteristics of gastric cancer, could be regarded as a reference index.