Comparative Study Of Effects Of Potassium Iodide And Iodate On Lens Of Iodine Deficiency Rats

Objective: The purpose of our study is to explore if there is any difference between effects on the lenses of iodine deficient rats by potassim iodide(KI) and potassim iodate(KIO₃) in different dosages.Methods: First of all,Wistar rat model of iodine deficiency was made.Then rats were randomly divided into four groups:normal iodide group(NI), high iodide group(HI), normal iodate group(NO)and high iodate group (HO). Rats were killed after 22 weeks, then wet weights, levels of antioxidase and MDA contents of rat lenses homogenate were investigated by using biochemical methods.Results: l.There was statistical difference in wet wetight of rat lens among the four groups (p<0.05).The wet weight of lens in group HO was the lowest of four groups. There was significant statistical difference between group HO and NI in wet weight of lens(p<0.01). Compared with wet weight of group NI,that of group HO decreased significantly(p<0.01). 2.There was statistical difference in the superoxide dismutase(SOD) level of lens homogenate among the four groups (p<0.01).The SOD level in group HO was the lowest of four groups.Compared with the SOD level of group NI,that of group HO decreased significantly(p<0.01).So did it compared with the SOD level of group NO (p<0.05);There was statistical difference in the glutathione peroxidase(GPx) level of lens homogenate among the four groups (p<0.05). The GPx level in group HO was the lowest of four groups. Compared with the GPx level of group NL NO,that of group HO decreased significantly (p<0.05) J.There was no statistical difference in malondialdehyde (MDA) content of lens homogenate among the four groups (p>0.05) ; There was statistical difference in SOD/MDA value of lens homogenate among the four groups (p<0.05).The SOD/MDA value in group HO was the lowest of four groups.Compared with the SOD/MDA value of group NI,that of group HO decreased significantly(p<0.05); There was statisticaldifference in GPx /MDA value of lens homogenate among the four groups (p<0.05).The GPx/MDA value in group HO was the lowest of four groups.Compared with the GPx/MDA value of group NL NO,that of group HO decreased significantly(p<0.05).Conclusions: The study shows that:l.There was no difference among iodine deficent rats given normal dosage of potassium iodide for 22 weeks and iodine deficent rats given normal dosage of potassium iodate for 22 weeks in antioxidative capability of lens.2.There was no difference among iodine deficent rats given high dosage of potassium iodide for 22 weeks and iodine deficent rats given high dosage of potassium iodate for 22 weeks in antioxidative capability of lens.3.There was no difference among iodine deficent rats with given normal dosage of potassium iodide for 22 weeks and iodine deficent rats given high dosage of potassium iodide for 22 weeks in antioxidative capability of lens.4.There was considerable difference among iodine deficent rats given normal dosage of potassium iodate for 22 weeks and iodine deficent rats given high dosage of potassium iodate for 22 weeks in antioxidative capability of lens, rats given high dosage of potassium iodate had lower antioxidative capability than rats given normal dosage of potassium iodate. 5.Iodine deficent rats given high dosage of potassium iodate for 22 weeks had lower wet wetight of rat lens than iodine deficent rats given normal dosage of potassium iodide.6.Iodine deficent rats given high dosage of potassium iodate for 22 weeks had lower antioxidative capability than iodine deficent rats given normal dosage of potassium iodide.7.There was no difference in lipid peroxidation levels of lens among iodine deficent rats given different dosages of different iodine compounds for 22 weeks. So excessive supplement of potassium iodate might be harmful for lens.