Tolterodine In The Treatment Of Bladder Spasm And Early Detrusor Instability After Transurethral Resection Of The Prostate

Objective: To evaluate the efficacy and tolerability of tolterodine in the control of bladder spasm and micturitional symptoms of unstable bladder during the early stage after transurethral resection of the prostate(TURP).Methods: This was a single-blind,randomized controlled trial. Thirty-eight patients who underwent TURP for symptomatic benign prostatic hyperplasia were randomly divided into tolterodine group and controll group, tolterodine group patients received tolterodine(2mg twice daily) after TURP,control group patients didn't receive tolterodine.Results:The symptoms score ,the number of bladder spasm episodes, duration of bladder spasm, the time of bladder perfusion clearance, indwelling catheter delivery in tolterodine group reduced significantly as compared with controll group. After removal of catheter ,the number of voids per day, mean urine volume per void, number of incontinent episodes in tolterodine group improved significantly as compared with controll group. The rate of dry mouth was 40% for tolterodine group, 16.7% for controll group.Conclusionrtolterdine 2mg twice daily is effective and well tolerated in the prevention and treatment of postoperative bladder spasm, tolterodine could also significantly alleviates early irritative symptoms after TURP.