Main Pharmacodynamics Study On Spring Rain Burns Ointment

The prescription of Spring Rain Burns Ointment(SRBO) was summarized by our province famous expert of TCM of Wang Qicheng director pharmacist. SRBO is our hospital preparation. The primitive preparation used China Wood Oil and Lime as bases and made by Rhizoma Coptidis and Rhizoma Polygoni Cuspitudi etc. After approval establishment project, to overcome the shortage of bases, through screening time and again in the study, in the premise of not changing principal medicine, according the feature of emulsifiers, applying Stearic Acid and Glyceryl Monostearate as bases, the preparation is stabler and more convenient than ever. To verifying its bases for efficacy which is defined by the theory of TCM, according to The Guide of New Drug of TCM, referring Methodology on Pharmacology of TCM and Methodology on Pharmacology of Experiment, using Moist Exposed Burn Ointment(EMBO) as contrast, designing experiment of anti-inflammatory, analgesia, anti-bacterial, anti-infection, burn wound healing, the writer has studied its main pharmacodynamics. The results: Every dosage of SRBO have obvious anti-inflammatory effect in the experiment of mice ears corner induced inflammatory by Dimethyl Benzene and rats paws induced inflammatory Carrageenan. There is anti-inflammatory effect in swelled paws experiment after 5min for taking medicine. The effect can maintain over 6h on medium and highdosages. There is apparent analgesia effect in the experiment of mice hot plate and Acetic Acid analgesia. There are significant differences on high dosages between SRBO and EMBO. The validity analgesia time can achieve over 2h in hot plate inducing-pain experiment. In vitro anti-bacterial experiment: Every dosage to streptococcus aureus and pseudomonas aeruginosa has well anti-bacterial effect. The extent of anti-bacterial depends at the dosages. SRBO is better than EMBO on anti- streptococcus. There are no significant differences at high dosages between SRBO and EMBO anti- pseudomonas. In vivo anti-bacterial experiment: There are very significant differences between SRBO and blank or bases on anti-the two bacterial. SRBO can produce effects quickly in 24h. SRBO is better than EMBO on anti- streptococcus at the speed and strength. On anti-pseudomonas there are very significant differences between drugs and blank or bases and there are no significant differences at medium and high dosages between SRBO and EMBO. In wound heeling experiment: In shallow second degree burn experiment, at three dosages there are very significant differences between SRBO and blank or bases and there are no significant differences between SRBO and EMBO. In deep second degree burn after bacterial inoculated experiment: At every dosage there are very significant differences between SRBO and blank or bases. SRBO produce a better curative effect than EMBO. It can be proved by pathologic tissue check. At the burn animals weight increasing tendency, SRBO is better than blank, bases or EMBO.Conclusion: SRBO has the effects of anti-inflammatory, analgesia, anti-bacterial, anti-infection, improving wound tissue structure and promoting burnwound healing. It offers foundation for clinic curative effect and display the drug excellent prospect on application.