Exercise Scintirenography In Normotensive Young Offspring Of Essential Hypertensive

Objective: To observe whether there is potentl i renal function decline in normotensive young offspring of essential hypertensives and to probe into the possible mechanism giving rise to it, providing some clues to the study of the pathogenic and hereditary mechanism of essential hypertension. Methods: Using 99mTc-DTPA as the imaging agent, we perfored rest and exercise scintirenography in normotensive young offspring of essential hypertensives(NOH)(31 cases, 14 male, 17 female mean age ±SD: 23.2 ±4.1 years), normotensive young offspring of non-hypertensives(NON) (31ceases, 20 male, 11 female; mean age ±SD: 23.1 ±3.6 years), some of the hypertensive parents(21cases, 5 male, 16 female; mean age±SD: 53.0 ± 5.61 years) and old non-hypertensive subjects:(10 cases, 6 male, 4 female; mean age±SD: 53.7±5.2 years). The results were analyzed with the software of SPSS 10.0 for Windows. Results: Though all of the rest renal functional indexes from NOH were within the normal range, there were significant difference between most of those from NOH and those from NON, e.g., TP and MTT from NOH were significantly delayed than those from NON; exercise made this difference more significant, and after exercise, GFR and RI were significantly lower, and 20/P as significantly higher. There were 4, 5, 2 cases showing abnormal exe: ise scintirenography in NOH, hypertensive parents and old non-hypertensi e subjects respectively, none in NON group. Conclusion: There is potential renal function decline in normotensive young offspring of essential hypertensives. The kidney may play an important role in the pathogenic and hereditary mechanism of essential hypertension. The old's renal function gradually declined with aging similar to the hypertensive.