Effect Of Carthamus Tinctorius L. On Inhibiting Platelet In Coronary Heart Disease And The Mechanism Of Anti-myocardial Ischemia

Objectives: To explore the effect of Carthamus Tinctorius L. (CTL) on platelet-whether it has effect of "Asprin-like" and the mechanism of anti-myocardial ischemia.Methods: 100 patients with stable angina pectoris aged 40 to 70 were randomly divided into two groups. One group was given CTL 5.0g/d, another group was given aspirin 50mg/d. Both group nitrates. After treating 2 months, TXA2, PGI2 and total cholesterol(TC), triglyceride(TG), low-density lipoprotein-chlesterol (LDL-C) and high-density lipoprotein-cholesterol(HDL-C) were analysed. The changes of myocardial ischemia and blood pressure were measured with synchronous 12-lead ECG machine, dynamic electrocardiogram and dynamic blood pressure monitoring.The symptoms at ordinary times were recorded and the changes of clinical manifestations were observed.Results: TXA2 was remarkably decreased after CTL administration (p<0.05), but PGI2 was not changed; Compared with aspirin group, TC and LDL-C were significantly decreased (all p<0.05) in CTL group. The symptoms of angina pectoris and ECG were remarkably improved (P<0.01) in CTL group. Total stress of myocardial ischemia in CTL group was also lower than in aspirin group.Conclusion: These results confirm that CTL has effects of "Aspiri-like" on inhibiting platelet in coronary heart disease. The study indicate that CTL is able to inhibit TXA2, dilate blood vessel, reduce blood pressure, decrease TC and LDL-C. CTL can also relieves the symptoms of angina pectoris remarkably.