Comparative Study Of HLA-DQA1 Allele Polymorphism In Patients With Asthma And Chronic Bronchitis

Objective The objective of this study was to compare HLA-DQA1 allele frequencies in the case of asthma with that in the case of chronic bronchitis.Methods The author investigated 40 patients with asthma and 21 patients with chronic bronchitis from the Han people in Jiangxi province.HLA-DQA1 alleles were determined using PCR-RFLP genotype method,and the patients'data were compared with that of health controlled group.Results Compared with the health controls,the frequencies of HLA-DQA1*0401 alleles were significantly increased in the asthma group(P﹤0.01) and the chronic bronchitis group(p﹤0.01),and the frequency of HLA-DQA1*0601 allele was significantly increased in the asthma group(P﹤0.01) .But the frequencies of HLA-DQA1*0401 *0601 alleles in the asthma group were not significantly different compared with the chronic bronchitis group(P﹥0.05).The frequencies of other DQA1 alleles were not significantly different in these groups.Conclusion The results indicate that HLA-DQA1*0401, *0601alleles may be susceptible genes of asthma, and HLA-DQA1*0401 allele may be susceptible gene of chronic bronchitis among the Hans in Jiangxi provine,suggesting that asthma is the partial same as chronic bronchitis in genetic immune mechanism.