| In modern agriculture, organophosphoms pesticide is used widely in production , transport, sale, and preservation. Excessive contact, polluted food, or accident taking may cause poisoning. In this kind of poisoning, 70 to 80 percent were organophosphorus insecticide poisoning and the fatality rate was over 10 percent. With the development of economics and society, pressure on people from the society and family is increased. Caused by psychological imbalance, people taking agricultural chemical are getting more and more, especially in outlying areas.Respiratory failure is the main cause of death from acute organophosphorus poisoning. However, few articles has been published on pulmonary function of patients with organophosphorus poisoning. Based on the routine examination of 12 patients with organophosphorus poisoning, we determined their functions of respiratory muscles and excitability of respiratory center to discuss the clinical significance.Materials and MethodsPatientsTwelve patients diagnosed as organophosphorus poisoning were admitted to the intensive care unit of Emergency Department of our hospital from January 2002 to December 2003. All of them needed mechanical ventilation. With average age of 28. 1 11.5 years old and average body weight of 53. 2 kilograms, there were 4 men and 8 women. The symptoms of all these patients meet the di-agnostic standards for organophosphorus poisoning according to the fifth edition of Internal Medicine. At the end of treatment, all patients get off their respirators successfully.Twelve healthy people were as controls, with 5 men and 7 women and average age of 27.3 11.3 years old and average body weight of 51. 6 kilograms.MachinesMachines included respirator ( USA ) , respiratory physiologic surveyor ( USA) , blood gas analyzer ( USA ) , and full - automatic dry chemistry analyzer (USA).MethodsBy using the programs in the respirator, we determined the maximal inhaled pressure (MIP) and oral blocking pressure (P0.1) in the patients with organophosphorus poisoning. The MIP and P0.1 in the healthy controls were determined by using the respiratory physiologic surveyor. In all patients and controls, the blood gas indexes were determined by using the blood gas analyzer, and in the patients the activity of serum cholinesterase ( CHE) was determined by using the full - automatic dry chemistry analyzer.Steps1 Before taking off the respirators in the patients, we set up the parameters of the respirators as following: pressure support was 8 cmH2O 35% oxygen content inhaled, and 0 of respiratory frequency. Through inferior nasal esopha-geal balloon, the oral blocking pressure ( P0.1) of the patients were determined. In the healthy controls, after normal respiration for 3 to 4 cycles, the airway were blocked at the end of expiration, and the P0.1 , was recorded 0.1 second after inspiration by using the respiratory physiologic surveyor. The average was calculated after determination for 2 to 3 times.2 Before taking off the respirators in the patients, we stopped the respirators. The patients were told to take forced breath and the maximal negative pressure was determined as the maximal inhaled pressure ( MIP) after 3 times of determination. In the healthy controls, the MIP was determined by using the modified Black method and respiratory physiologic surveyor. The controls kept quiet for 10 minutes and took sitting position. After a force inhalation, the surveyorshowed the MIP, and the controls hold breath for at least 1 second and then returned to normal breath. The MIP was determined after 3 times of determination.3 In all patients and controls, the blood gas indexes including partial pressure of oxygen in arterial blood ( PaO2) , partial pressure of carbon dioxide ( PaCO2) , and acidity and alkalinity ( pH) were determined in 2 millilitre of radial artery blood by using the blood gas analyzer. In the patients, the activity of serum cholinesterase ( CHE) was determined in 4 millilitre of venous blood by using the full - au...
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