| The coronary atheroslotic cardiopathy (CHD) means that ischemia and hypoxia owing to coronary stenosis and blocking made by coronary atherolerotic apaque. Its morbidity is increasing recently . Traditional Chinese Medicine run a important role and has a unperelleled superiority in curing CHD. YiXin capsule is a effective compound herbal pharmaceutics devised and manufactured by Harbin Quanyi pharmaceutical factory on the basis of many specialists' clinical experience over many years whose efficacy is Huoxuehuayu and Xingqihuotan, it has completed animal experiment of protecting acute myocardial ischemia induced by the desending anterior branch of coronary ligation .Now YiXin capsule has been approved by Nation medicine administer bureau and entered HI stage clinic. To study furthermore its definite mechanisms of action, we selected the chronic myocardial ischemia model of rat made by small-dose and repeatedly subcutaneneous injection to observe the effection of endothelin in blood plasma and myocardial tissue as well as the change by means of biochemistry and pathomorphology applied.The results indicate that YiXin capsule can decrease ET in blood plasma and myocardial tissue and improve the injure of ischemic myocardial Pathomorphology .We can draw conclusion that YiXin capsule can prevent and treat CHD.
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